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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus

Figure 3

Epratuzumab induces β1 integrin on CD27negative B-cells. In order to analyse changes in the surface expression of β1 integrin on B-cell sub-populations (CD27negative B-cells and CD27positive B-cells), we incubated PBMCs for 90 minutes at 37°C, 5% CO2 without epratuzumab (first line), or with human IgG1 (second line) or with epratuzumab (third line) (n = 3). The histograms are representative of three independent experiments and the results are summarized in Figure 3 (mean ± SEM).

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