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Table 1 Rat genes up- and down- regulated two-fold or higher in nucleus pulposus cells co-cultured with human synovial MSCs

From: Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits

Genes Genbank Fold change
Collagens   
   Col2a1 [Genbank:AF305418] 10.5
   Col1a1 [Genbank:Z78279] -2.3
   Col5a1 [Genbank:NM_134452] -7.1
   Col5a3 [Genbank:NM_021760] -25.3
Proteoglycans   
   Chondroitin sulfate proteoglycan 2 [Genbank:AF084544] 2.9
   Biglycan [Genbank:NM_017087] -7.6
   Glypican 1 [Genbank:NM_030828] -13.4
   Lumican [Genbank:NM_031050] -16.1
   Chondroitin sulfate proteoglycan 4 [Genbank:NM_031022] -18.1
Tissue inhibitor of metalloproteinases   
   TIMP-3 [Genbank:NM_012886] 27.3
   TIMP-1 [Genbank:NM_053819] -2.1
   TIMP-2 [Genbank:NM_021989] -4.7
Matrix metalloproteinases   
   MMP-23 [Genbank:NM_053606] -2.0
   MMP-16 [Genbank:NM_080776] -3.0
   MMP-11 [Genbank:NM_012980] -3.7
   MMP-14 [Genbank:X83537] -6.0
   MMP-3 [Genbank:NM_133523] -44.5
   MMP-13 [Genbank:M60616] -59.7
   MMP-2 [Genbank:U65656] -82.7
Interleukin related   
   Nuclear factor, IL-3 regulated [Genbank:NM_053727] -2.3
   IL-15 [Genbank:AF015718] -3.5
   IL-6 signal transducer [Genbank:AI171807] -7.4
   IL-11 receptor, alpha chain 1 [Genbank:AF347936] -9.3
Tumor necrosis factor related   
   TNF receptor superfamily, member 1a (TNFRSF1A) [Genbank:NM_013091] -2.0
   TNF-α converting enzyme [Genbank:NM_020306] -2.6
   TNF-α induced protein 6 (TSG-6) [Genbank:AF159103] -5.4
   Type 1 TNF receptor shedding aminopeptidase regulator [Genbank:NM_030836] -9.0
   TNF receptor superfamily, member 6 (TNFRSF6) [Genbank:BE108106] -12.5
  1. A total of 15,779 rat genes consistent with the quality criteria, genes in collagens, proteoglycans, tissue inhibitor of metalloproteinases, matrix metalloproteinases, interleukin-, and tumor necrosis factor-related genes are listed. IL, interleukin; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase; TNF, tumor necrosis factor.