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Table 4 Analysis of gene expression at the end of the 5-day treatment perioda

From: Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation

   ADAMTS4 ADAMTS5 MMP3 MMP9 MMP13 COX2
EPA 0.1 μM x
  1 μM x x
DHA 0.1 μM x x x x x x
  1 μM x x x x x x
  1. aAll six catabolic/inflammatory genes were upregulated in the IL-1β-treated explants relative to untreated controls. Arrows (↓) indicate a reduction in the IL-1β-induced increase in gene expression associated with EPA or DHA treatment. EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; MMPs, matrix metalloproteinases; COX, cyclooxygenase; ADAMTS, a disintegrin and metalloproteinase with a thrombospondin type 1 motif.