Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation

Table 4 Analysis of gene expression at the end of the 5-day treatment period^a

		ADAMTS4	ADAMTS5	MMP3	MMP9	MMP13	COX2
EPA	0.1 μM	↓	↓	↓	x	↓	↓
	1 μM	↓	x	↓	x	↓	↓
DHA	0.1 μM	x	x	x	x	x	x
	1 μM	x	x	x	x	x	x

^aAll six catabolic/inflammatory genes were upregulated in the IL-1β-treated explants relative to untreated controls. Arrows (↓) indicate a reduction in the IL-1β-induced increase in gene expression associated with EPA or DHA treatment. EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; MMPs, matrix metalloproteinases; COX, cyclooxygenase; ADAMTS, a disintegrin and metalloproteinase with a thrombospondin type 1 motif.

ISSN: 1478-6362