Figure 7

Effects of UC-MSCs on T cell subtypes in CIA model. (a) UC-MSCs downregulated Th1-type response. UC-MSCs decreased the number of IFNγ-producing Th1 cells, n = 6, **P < 0.01. All the data are expressed as the mean ± SD. (b) UC-MSCs upregulated Th2-type response. UC-MSCs increased the number of IL4-producing Th2 cells. N = 6, **P < 0.01. All the data are expressed as the mean ± SD. (c) UC-MSCs tended to decrease Th17-type response. UC-MSCs tend to decrease the number of IL-17-producing Th17 cells. N = 6. All the data are expressed as the mean ± SD. (d) UC-MSCs treatment induced Tregs in CIA. Percentages of CD4⁺FoxP3⁺ cells in spleen and peripheral blood in UC-MSCs treated group were higher than the PBS control group. N = 6, **P < 0.01. All the data are expressed as the mean ± SD. (e) As compared with Tregs isolated from PBS-treated mice, CD4⁺CD25⁺ T cells isolated from UC-MSC-treated mice functioned as suppressive Tregs, since they inhibited the proliferation of effective T cells (Teff). N = 6, **P < 0.01. All the data are expressed as the mean ± SD.