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Table 3 Associations of composite risk factors with ACPA positivity in patients with rheumatoid arthritisa

From: Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferasein a cross-sectional study

 

VARA (n= 703)

SONORA (n= 610)

 

ACPA+

(%)

OR (95% CI)

Pvalue

ACPA+

(%)

OR (95% CI)

Pvalue

GSTM1/SEa,b

      

   Present/Negative

50

Ref.

-

59

Ref.

-

   Null/Negative

56

1.26 (0.68 to 2.33)

0.456

48

0.63 (0.35 to 1.15)

0.135

   Present/Positive

79

3.65 (2.09 to 6.40)

< 0.001

72

1.79 (1.05 to 3.03)

0.032

   Null/Positive

88

7.30 (4.01 to 13.29)

< 0.001

77

2.29 (1.34 to 3.90)

0.002

 

AP = 0.46 (0.20 to 0.73)

AP = 0.38 (0.00 to 0.76)

 

Padd < 0.001

Padd = 0.050

 

Pmult = 0.246

Pmult = 0.063

GSTM1/Smokinga

      

   Present/Never

67

Ref.

-

72

Ref.

-

   Present/Ever

75

1.42 (0.80 to 2.52)

0.227

67

0.72 (0.42 to 1.22)

0.223

   Null/Never

72

1.35 (0.65 to 2.79)

0.421

67

0.75 (0.42 to 1.36)

0.349

   Null/Ever

81

2.01 (1.13 to 3.55)

0.017

70

0.83 (0.49 to 1.42)

0.502

 

AP = 0.12 (-1.41 to 1.65)

AP = 0.44 (-0.28 to 1.15)

 

Padd = 0.881

Padd = 0.231

 

Pmult = 0.917

Pmult = 0.245

SE/Smokinga

      

Negative/Never

55

Ref.

-

58

Ref.

-

Negative/Ever

53

0.90 (0.40 to 1.99)

0.788

51

0.73 (0.39 to 1.37)

0.329

Positive/Never

73

2.24 (0.97 to 5.16)

0.058

74

2.03 (1.08 to 3.82)

0.027

Positive/Ever

87

5.05 (2.31 to 11.05)

< 0.001

75

2.10 (1.17 to 3.78)

0.013

 

AP = 0.58 (0.31 to 0.85)

AP = 0.16 (-0.34 to 0.66)

 

Padd < 0.001

Padd = 0.530

 

Pmult = 0.054

Pmult = 0.380

  1. aACPA, anticitrullinated protein antibody; AP, attributable proportion; GSTM1, glutathione S-transferase Mu-1; SE, shared epitope; SONORA, Study of New-Onset Rheumatoid Arthritis; VARA, Veterans Affairs Rheumatoid Arthritis. All analyses are age- and gender-adjusted. bCorresponding ORs and 95% for GSTM1/SE composite risk after further adjustment for ever smoking in VARA: Null/Negative OR = 1.22 (0.66 to 2.27); Present/Positive OR = 3.75 (2.13 to 6.59); Null/Positive OR = 7.34 (4.02 to 13.34); in SONORA, Null/Negative OR = 0.65 (0.36 to 1.18); Present/Positive OR = 1.80 (1.06 to 3.06); Null/Positive OR = 2.31 (1.36 to 3.95). "Ref." = referent group in each analysis.
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Arthritis Research & Therapy

ISSN: 1478-6362

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