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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases

Figure 4

Spleen tyrosine kinase (Syk)-mediated signal transduction in platelets. Signal transduction pathways are mediated through αIIbβ3 integrin/FcγRIIA, CLEC-2, and GPVI/FcRγ. GPVI and αIIbβ3 use ITAM, whereas CLEC2 uses atypical ITAM. These three pathways of Syk activation result in platelet activation through SLP76 and PLCγ2. CLEC2, C-type lectin-like receptor 2; FcRγ, Fc receptor γ-chain; GPVI, glycoprotein VI; ITAM, immunoreceptor tyrosine-based activation motif; PLCγ2, phospholipase Cγ2; SH2, Src homology 2; SLP76, SH2 (Src homology 2) domain-containing leukocyte protein 76.

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Arthritis Research & Therapy

ISSN: 1478-6362

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