Figure 6

Mechanisms of monosodium urate (MSU)-mediated inflammation and the roles of spleen tyrosine kinase (Syk) and Nlrp3. MSU signals activate Nlrp3 inflammasome. Syk plays important roles in both pro-IL1β synthesis and Nlrp3 activation in response to MSU. Pro-IL1β synthesis occurs through the Syk-Card9 pathway. However, Nlpr3 activation is regulated through a Syk-dependent, mostly Card9-independent mechanism. Card9, caspase recruitment domain 9; IL1β, interleukin-1-beta; NF-κB, nuclear factor-kappa-B; Nlrp3, NLR family pyrin domain-containing 3; SH2, Src homology 2.