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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Differentiation of monocytes into multinucleated giant bone-resorbing cells: two-step differentiation induced by nurse-like cells and cytokines

Figure 1

Morphology of TRAP-positive mononuclear cells induced from peripheral-blood monocytes with RA-NLCs. (a) Phase-contrast micrograph of monocytes co-cultured with RA-NLCs. Mononuclear cells (arrow) are growing on the RA-NLCs. (b) Mononuclear cells collected from the culture shown in (a). May–Grunwald–Giemsa staining. (c) Detection of TRAP expressed by the mononuclear cells (TRAP-positive cells were stained red with their cytoplasm). (d) Differentiated mononuclear cells. The cells shown here are multinucleated giant cells. May–Grunwald–Giemsa staining. Scale lines = 100 –m.

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