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Table 1 Recognition of citrullinated fibrinogen peptide-containing fractions by RA sera

From: Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance

Strongly reactive fractionsa

% reactive sera

Moderately reactive fractionsb

% reactive sera

Non reactive fractionsc

T32

75

T31

54

C12

T27

57

L34

47

C14

C8

51

C10

44

C22

T28

51

L33

43

C25

T26

50

C27

36

C31

L37

46

L27

36

C34

L28

39

C29

33

L24

T29

39

C28

30

L26

T24

36

C30

25

L29

    

L30

    

L31

  1. a Fractions that are recognized by at least 25% of the RA sera with reactivities exceeding a cut-off value of the mean plus 8 times the standard deviation of anti-CCP-negative sera. T, C and L refer to the proteases used to fragment citrullinated fibrinogen; numbers correspond to fraction numbers of the fractionation by cation exchange chromatography.
  2. b Fractions that are recognized by at least 25% of the RA sera with reactivities exceeding a cut-off value of the mean plus two times the standard deviation of anti-CCP-negative sera.
  3. cThe remaining fractions that were analysed.
  4. RA, rheumatoid arthritis.