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Table 1 Characteristics of participants according to presence or absence of BMLs at baseline at each site*

From: Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults

  Medial tibial Medial femoral Lateral tibial Lateral femoral
  BML absent BML present BML absent BML present BML absent BML present BML absent BML present
  (n= 352) (n= 53) (n= 358) (n= 47) (n= 379) (n= 26) (n= 356) (n= 49)
Age (year) 63.2 (7.2) 63.5 (7.2) 63.3 (7.3) 62.7 (6.3) 63.1 (7.3) 65.0 (6.4) 63.3 (7.2) 63.0 (7.6)
Male sex (%) 49 53 49 57 50 46 47 65†
BMI (kg/m2) 27.6 (4.4) 28.0 (4.8) 27.5 (4.5) 28.5 (4.0) 27.7 (4.5) 26.6 (2.7) 27.7 (4.5) 27.2 (4.1)
Cartilage defects present baseline# (%) 7 28‡ 15 43‡ 15 38‡ 5 31‡
Cartilage defect increase (%) 13 25† 23 44‡ 14 52‡ 17 41‡
Cartilage volume baseline (mL) 2,332 (580) 2,352 (563) 3,949 (1,135) 4,024 (1,089) 2,763 (681) 2,687 (807) 4,327 (1,194) 4,351 (876)
Cartilage volume loss per annum (%) -2.3 (5.3) -4.4 (5.1)† -1.1 (2.1) -2.2 (2.9)‡ -1.8 (4.0) -4.7 (6.2) ‡ -0.8 (2.0) -1.7 (1.9)†
BML increase (%) 11 17 5 15† 11 12 12 27‡
  1. *Mean (standard deviation) except for percentages. Bold denotes a statistically significant result. P-values determined by t-test or chi-square test (where appropriate).
  2. P < 0.05.
  3. P < 0.01.
  4. #Defined as grade 2 or higher.
  5. BMI, body mass index; BMLs, bone marrow lesions; mL, millilitre.