Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults

Table 3 Relationship between changes in WOMAC scores and changes in BML size*

	BML size change at all four sites**				Total BML size change
	Univariate (95% CI)	P	Multivariable (95% CI)†	P	Univariate (95% CI)	P	Multivariable (95% CI)†	P
No ROA
Pain change	0.57 (0.15, 0.99)	0.008	0.56 (0.19, 0.92)	0.003	1.06 (0.10, 2.03)	0.031	1.13 (0.28, 1.98)	0.009
Function change	1.20 (-0.08, 2.47)	0.067	1.25 (0.22, 2.28)	0.017	2.23 (-0.71, 5.17)	0.136	2.55 (0.14, 4.95)	0.038
Stiffness change	-0.01 (-0.20, 0.18)	0.925	0.04 (-0.13, 0.20)	0.664	-0.02 (-0.46, 0.43)	0.947	0.09 (-0.29, 0.48)	0.641
ROA Present
Pain change	0.07 (-0.29, 0.43)	0.715	0.03 (-0.28, 0.35)	0.844	0.11 (-0.54, 0.77)	0.733	0.06 (-0.53, 0.64)	0.848
Function change	0.16 (-0.77, 1.08)	0.740	0.13 (-0.62, 0.89)	0.729	0.26 (-1.41, 1.94)	0.756	0.23 (-1.17, 1.63)	0.750
Stiffness change	0.03 (-0.13, 0.19)	0.723	0.03 (-0.11, 0.17)	0.655	0.04 (-0.25, 0.34)	0.772	0.05 (-0.21, 0.30)	0.721

*Values are the change in pain, function, or stiffness score per one standard deviation change in BML size (mm²), stratified by ROA.
BML, bone marrow lesion; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index; ROA, radiographic osteoarthritis.
β, beta coefficients; 95% CI, 95% confidence interval.
**Medial tibial, medial femoral, lateral tibial, and lateral femoral.
†Adjusted for age, sex, body mass index, leg strength, quality of life, and baseline pain, function, or stiffness score depending on the model.
Boldface denotes statistically significant result

ISSN: 1478-6362