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Table 5 Relationship between knee replacement surgerynd baseline BMLs of the right knee*

From: Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults

  Univariate analysis Multivariate analysis
  OR (95% CI) P-value OR (95% CI) † P-value
Left knee replacement ( n = 7)     
   BML severity (0 to 8) 1.92 (1.40, 2.62) <0.01 2.78 (1.58, 4.90) <0.01
   BML presence/absence 4.60 (0.88, 24.05) 0.07 12.85 (1.82, 90.91) 0.011
Right knee replacement ( n = 8)     
   BML severity (0 to 8) 2.75 (1.81, 4.18) <0.01 2.88 (1.84, 4.52) <0.01
   BML presence/absence # 20.75 (3.17, α) <0.01 22.63 (3.72, α) <0.01
Knee replacement right and left ( n = 12)     
   BML severity (0 to 8) 2.04 (1.55, 2.69) <0.01 2.10 (1.13, 3.90) 0.019
   BML presence/absence 5.67 (1.51, 21.32) 0.01 5.67 (0.62, 51.77) 0.124‡
  1. *No knee replacement versus a knee replacement of the left, right, and right and left combined and baseline BMLs (measured on the ordinal scale and ranged from 0 to 12, which was the sum of the BML scores at all four sites).
  2. 95% CI, 95% confidence interval; BMLs, bone marrow lesions; OR, odds ratio
  3. #Using exact logistic regression because all 8 subjects who had a right knee replacement had a BML present.
  4. †Adjusted for age and sex.
  5. ‡Further adjusted for body mass index, knee pain, leg strength, cartilage defects, tibial bone area, and radiographic osteoarthritis.
  6. Boldface denotes statistically significant result.