| |
Univariate analysis
|
Multivariate analysis
|
|---|
| |
OR (95% CI)
|
P-value
|
OR (95% CI) †
|
P-value
|
|---|
|
Left knee replacement (
n
= 7)
| | | | |
|
BML severity (0 to 8)
|
1.92 (1.40, 2.62)
|
<0.01
|
2.78 (1.58, 4.90)
|
<0.01†
|
|
BML presence/absence
|
4.60 (0.88, 24.05)
|
0.07
|
12.85 (1.82, 90.91)
|
0.011†
|
|
Right knee replacement (
n
= 8)
| | | | |
|
BML severity (0 to 8)
|
2.75 (1.81, 4.18)
|
<0.01
|
2.88 (1.84, 4.52)
|
<0.01†
|
|
BML presence/absence #
|
20.75 (3.17, α)
|
<0.01
|
22.63 (3.72, α)
|
<0.01†
|
|
Knee replacement right and left (
n
= 12)
| | | | |
|
BML severity (0 to 8)
|
2.04 (1.55, 2.69)
|
<0.01
|
2.10 (1.13, 3.90)
|
0.019‡
|
|
BML presence/absence
|
5.67 (1.51, 21.32)
|
0.01
|
5.67 (0.62, 51.77)
|
0.124‡
|
- *No knee replacement versus a knee replacement of the left, right, and right and left combined and baseline BMLs (measured on the ordinal scale and ranged from 0 to 12, which was the sum of the BML scores at all four sites).
- 95% CI, 95% confidence interval; BMLs, bone marrow lesions; OR, odds ratio
- #Using exact logistic regression because all 8 subjects who had a right knee replacement had a BML present.
- †Adjusted for age and sex.
- ‡Further adjusted for body mass index, knee pain, leg strength, cartilage defects, tibial bone area, and radiographic osteoarthritis.
- Boldface denotes statistically significant result.
