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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model

Figure 3

Higher synovial inflammation and bone erosion in arthritic joints of Mmp8 -deficient mice than control mice. Representative sections of ankle joints of Mmp8-/- mice (a) to (c) and Mmp8+ mice (d) to (f) 9 days after intraperitoneal injection of K/BxN serum. More severe inflammation and pannus formation (arrows) were observed on hematoxylin and eosin stained sections from Mmp8-deficient mice (a) compared with control mice (d). More severe loss of proteoglycans indicated by destained cartilage was observed on Safranin-O stained sections from Mmp8-/- mice (b) compared with Mmp8+ mice (e). Increased tartrate-resistant acid phosphatase (TRAP)-positive multinucleated osteoclast-like cells (arrows) were observed at sites of bone erosions on sections stained for TRAP activity from Mmp8-deficient mice (c) compared with control mice (f).

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Arthritis Research & Therapy

ISSN: 1478-6362

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