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Figure 5 | Arthritis Research & Therapy

Figure 5

From: RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1

Figure 5

SLE CD4+T cells after transfection with RFX1 expression vector pSG5-RFX1, or with pSG5 (negative control). (a) Anti-RFX1 western blot of lysates from transfected CD4+ T cells. Anti-β-actin western blot is included as a loading control. (b) H3K9 tri-methylation levels at the CD11a and CD70 promoters in pSG5-RFX1-transfected CD4+ T cells relative to pSG5-transfected cells (*, P < 0.01; **, P < 0.05). (c) CD11a and CD70 mRNA levels in pSG5-RFX1-transfected CD4+ T cells relative to pSG5-transfected cells (*, P < 0.01; **, P < 0.05). Data represent the mean ± SD of three independent experiments per group.

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