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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases

Figure 1

Numerical chromosomal aberrations in the RA synovial membrane. Polysomy (hatched bars) and trisomy (shaded bars) of the individual chromosomes are depicted as means ± SEM for n = 7–13 patients. Polysomies in synovial tissue of RA patients exceeded threshold levels (broken lines) only in the case of chromosome 7. In P-1 synovial fibroblasts (FB), threshold levels were exceeded for polysomies of chromosomes 6, 7, 8, and 9. In P-4 synovial FB, threshold levels were exceeded for polysomies of chromosomes 6, 7, 8, 9, and 18 and monosomy 18; there was a clear increase between P-1 and P-4. Considering only trisomic nuclei, only aberrations in the numbers of chromosome 7 exceeded threshold levels, even in P-4 synovial FB. P-0 = primary culture; P-1 = passage 1; P-4 = passage 4.

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Arthritis Research & Therapy

ISSN: 1478-6362

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