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Supplementary Figure 1 | Arthritis Research & Therapy

Supplementary Figure 1

From: Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases

Supplementary Figure 1

Numerical chromosomal aberrations in the normal/JT synovial membrane. Polysomy (hatched bars) and trisomy (shaded bars) of the individual chromosomes in extracted nuclei from synovial tissue, nonseparated synovial cells (collagenase digest), and isolated synovial fibroblasts (FB; P-1, P-4) are shown as means ± SEM of n = 1–3 patients. The mean percentages of polysomies in normal/JT synovial tissue, collagenase digest, and P-1 synovial FB did not exceed threshold levels (broken lines). In P-4, the mean percentages of synovial FB polysomic for chromosomes 4, 6, 7, and 9 were elevated to levels above threshold. If instead of all polysomic nuclei, only trisomic nuclei were considered, there was no elevation of chromosomal aberrations above threshold levels, not even in P-4 synovial FB. P-0 = primary culture; P-1 = passage 1; P-4 = passage 4.

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