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Table 2 Cytogenetic findings in various cells/nuclei from patients with osteoarthritis

From: Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases

 

Karyotype and FISH resultsa

 

Peripheral

Nuclei

 

Synovial fibroblasts

 

blood

extracted from

Collagenase

  

Patient

lymphocytes

synovial tissueb

digest

P-1

P-4

ES37

46,XY

n.a.

n.a.

47,XY,+7[1]/46,XY [49]

47,XY,+7[2]/46, XY [48]

ES52

46,XX

n.a.

n.a.

46,XX

n.a.

ES53

46,XY

n.a.

n.a.

46,XY

n.a.

ES54

46,XX

n.a.

n.a.

46,XX

n.a.

L09

46,XX

n.a.

n.a.

47,XX,+7[12]/48,XX,+7,+8[5];46,XX[33]

n.a.

L11

46,XX

n.a.

n.a.

46,XX

n.a.

EB8

 

46,XY

n.a.

46,XY

n.a.

 

FISH: normal

FISH:+7 [4%];+8 [4%]; +9 [3%];-18 [7%]; incl. polyploid [1%]

 

FISH:+7 [17%];+8 [7%];+9 [9%]; -18 [19%]

 

EB9

46,XX

n.a.

n.a.

47,XX,+7[2]

n.a.

 

FISH: normal

 

FISH:+7 [52%]; -9 [4%]

FISH:+7 [n.a.]; -9 [25%]

 

EB10

46,XX

n.a.

n.a.

46,XX

n.a.

 

FISH: normal

 

FISH:+6 [6%];+7 [20%];+8 [11%];-8 [2%];-18 [8%]

FISH:+7 [32%];-8 [10%];-18 [18%]

 

EB11

46,XX

 

n.a.

47,XX,+7[3]/46,XX[7]

47,XX,+7[3]/46,XX[6]

 

FISH: normal

FISH:+4 [3%];+7 [8%];+18 [0%]

FISH:+4 [3%]; +7 [19%];+18 [2%]

FISH:+4 [7%];+7 [15%];+18 [8%]; incl. polyploid [7%]

 

EB12

45,X[10]/46,XX[17]

 

n.a.

47,XX,+7,+4 or +5[3]/46,XX[4]

46,XX

 

FISH:-X [32%]

FISH:+4 [0%];+7 [12%];+8 [12%];+9 [4%]

 

FISH:+4 [4%];+7 [42%];+8 [0%];+9 [11%]

FISH:+4 [2%];+7 [36%];+8 [1%];+9 [6%]

EB13

46,XY

n.a.

n.a.

46,XY

46,XY

 

FISH: normal

 

FISH:+7 [15%];-9 [3%];+12 [0%]

FISH:+7 [37%];-9 [8%];+12 [11%]

FISH:+4 [8%];+7 [16%]; +9 [5%];-9 [25%];+12 [6%]

EB14

46,XX

 

n.a.

47,XX,+7[3]/46,XX[7]

46,XX,+7,+8,-15,-21[1]/48,XX,+7,+9[1]/47,XX,+7[1]/48,X,+7,+8,+9[1]/46,X,-X,+7,-17,+mar[1]/46,XX,t(5;11)(q23;q12)[1]/48,X,-X, +5,+7,+8[1]/46,XX[1]

 

FISH: normal

FISH:+7 [14%];+8 [0%];+X [4%]

FISH:+7 [10%];+8 [0%];+X [6%]

FISH:+7 [36%];+8 [2%];+X [0%]

FISH:+7 [34%];+8 [8%];+X [6%]

EB15

46,XX

n.a.

n.a.

46,XX

n.a.

 

FISH: normal

  

FISH:+6 [7%];+7 [10%];+8 [7%];+9 [10%];incl. polyploid [7%]

FISH:+6 [12%];+7 [16%];+8 [7%];+9 [10%];incl. polyploid [4%]

EB16

46,XX

n.a.

n.a.

n.a.

n.a.

 

FISH: normal

 

FISH:+6 [5%]; +7 [18%];+8 [0%]; -X [18%]

 

FISH:+6 [26%];+7 [26%];+8 [35%];+X [17%];incl. polyploid [17%]

EB17

46,XX

n.a.

46,XX,chrb(1)(q12)[2]/46,XX[4]

46,XX

n.a.

 

FISH: normal

 

FISH:+4 [17%];+6 [3%];+12 [1%]

FISH:+4 [16%];+6 [6%];+12 [5%];incl. polyploid [1%]

 

EB18

46,XX

n.a.

46,XX

46,XX

n.a.

 

FISH: normal

 

FISH:+7 [1%];+8 [0%];+9 [2%]

FISH:+7 [5%];+8 [4%];+9 [1%]

FISH: +7 [18%];+8 [18%];+9 [18%];incl. polyploid [3%]

EB19

46,XX

 

46,XX

47,XX,+7[2]/46,XX[7]

47,XX,+7[2]/46,XX[6]

 

FISH: normal

FISH:+7 [18%];+8[2%];+9 [4%];+12 [4%];incl. polyploid [2%]

FISH:+7 [14%];+8 [0%];+9 [0%];+12 [0%]

FISH:+7 [10%];+8 [0%];+9 [4%];+12 [7%]

FISH:+7 [26%];+8 [18%];+9 [7%];+12 [8%];incl. polyploid [7%]

EB21

46,XX

n.a.

46,XX

46,XX

n.a.

 

FISH: normal

 

FISH:+4 [17%];+6 [7%];+7 [11%];+9 [17%]; incl. polyploid [5%]

FISH:+4 [3%];+6 [3%];+7 [5%];+9 [3%]; incl. polyploid [1%]

FISH:+4 [3%];+6 [4%];+7 [11%];+9 [3%]; incl. polyploid [3%]

EB22

46,XY

n.a.

n.a.

46,XY

n.a.

 

FISH: normal

 

FISH:+4 [4%]; +7 [7%];+9 [3%]; incl. polyploid [1%]

FISH:+4 [2%];+7 [6%];+9 [1%]; incl. polyploid [1%]

FISH:+4 [8%];+7 [8%]; +9 [7%]

EB24

46,XX

 

n.a.

46,XX

n.a.

 

FISH: normal

FISH:+4 [0%];+6 [3%];+7 [7%];+9 [3%]

FISH:+4 [8%];+6 [8%];+7 [25%];+9 [8%]; incl. polyploid [7%]

FISH:+4 [9%];+6 [2%];+7 [33%];+9 [3%]; incl. polyploid [2%]

FISH:+4 [2%];+6 [2%];+7 [24%];+9 [3%]; incl. polyploid [2%]

EB29

46,XX

n.a.

n.a.

n.a.

n.a.

 

FISH: normal

    

J4

n.a.

 

n.a.

46,XX

46,XX

  

FISH:+4 [5%];+7 [14%]; incl. polyploid [1%]

 

FISH:+4 [1%];7 [6%]; incl. polyploid [1%]

 

J5

n.a.

 

n.a.

n.a.

n.a.

  

FISH:+4 [5%];+7 [13%]

   
  1. aSee Table 1. b Only FISH data are available. incl. = including; n.a. = not analyzed (Karyotype and/or FISH); P-1 = passage 1; P-4 = passage 4.