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Figure 8 | Arthritis Research & Therapy

Figure 8

From: Salivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survival

Figure 8

Triple staining of CXCL12, PNAd and CD138 in salivary glands of pSS patients and non-SS controls. A) Amounts of PNAd+ HEVs in the interstitium and B) in the focal infiltrates in salivary glands presented as number of cells per mm2. Grey bars represent FS = 1 (n = 9), black bars represent FS ≥2 (n = 10), striped bars represent chronic inflammation (n = 5) and white bars represent normal gland histology (n = 5). Results presented as mean ± SEM. Statistical analyses determined by Kolmogorov-Smirnov and Student t-test (*P < 0.05, **P < 0.005 and ***P < 0.001). C) CXCL12 expression (blue), PNAd expression (red) and CD138+ plasma cells (brown) detected in a pSS patient with FS = 1, a pSS patient with FS = 4, in a subject with chronic inflammation and a subject with normal gland histology. PNAd +HEVs were mainly detected in the close proximity or inside of the infiltrates in the pSS glands. CD138+ plasma cells were observed tightly adherent to both CXCL12 positive and CXCL12 negative HEVs. However, only few HEVs expressed CXCL12. D) Higher magnification of CXCL12 expression (blue) detected in some of the PNAd+ HEVs (red).

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