Figure 1

Disease activity score and immunoglobulin G galactosylation in relation to mannose-binding lectin genotype groups. (a) Mean rheumatoid arthritis (RA) disease activity score 28 (DAS28) during pregnancy and postpartum (PP) in relation to mannose-binding lectin (MBL) production genotype groups A (high), B (intermediate) and C (low). No significant difference in DAS28 levels is observed between MBL genotype groups A, B and C at all time points during pregnancy and postpartum (P = 0.899). (b) Mean Immunoglobulin G1 (IgG1) galactosylation (×100%) of patients with RA during pregnancy and postpartum per MBL production genotype group. No significant difference in IgG galactosylation levels is observed between MBL genotype groups A, B and C at all time points during pregnancy and postpartum (P = 0.75). Data for IgG2 galactosylation and for the controls show similar results (data not shown). The vertical bars indicate the 95% confidence intervals. trim, trimester of pregnancy; wk, weeks; PP, postpartum; mon, months.