Single-nucleotide polymorphisms and haplotype of CYP2E1gene associated with systemic lupus erythematosus in Chinese population

Table 1 Association analysis of four tag SNPs and haplotypes with SLE in the stage I study

		No.
SNP		Controls	Cases	Crude OR (95% CI)	Crude P	Adjusted OR (95% CI)	Adjusted P
rs2031920
allelic	C	462	401	1.081 (0.804 to 1.454)	0.604	1.029 (0.887 to 1.195)	0.703
	T	114	107
geonotypic	C/C+C/T	184 + 94	159 + 83	1.379 (0.585 to 3.247)	0.461	1.151 (0.749 to 0.176)	0.52
	T/T	10	12
rs2070672
allelic	A	480	430	0.907 (0.655 to 1.256)	0.557	0.968 (0.821 to 1.142)	0.701
	G	96	78
geonotypic	A/A+G/G	199 + 7	186 + 10	0.743 (0.504 to 1.096)	0.135	0.753 (0.508 to 1.115)	0.156
	A/G	82	58
rs8192772
allelic	T	454	426	0.913 (0.681 to 1.224)	0.542	0.970 (0.837 to 1.125)	0.686
	C	122	102
geonotypic	T/T + T/C	171 + 112	174 + 76	3.170 (1.126 to 8.925)	0.022	1.912 (1.131 to 3.234)	0.016
	C/C	5	14
rs2480256
allelic	G	360	295	1.282 (1.007 to 1.633)	0.043	1.128 (0.999 to 1.274)	0.053
	A	216	223
geonotypic	G/G+G/A	106 + 148	93 + 109	2.182 (1.377 to 3.459)	0.001	1.475 (1.170 to 1.860)	0.001
	A/A	34	59
Haplotype (rs2031920-rs2070672-rs8192772-rs2480256)		Frequency in the Control	Frequency in the SLE	OR (95% CI)	P -value
CATG		58.50%	54.70%	0.856 (0.674 to 1.088)	0.205
TATA		15.70%	19.70%	1.321 (0.967 to 1.803)	0.081
CGCA		15.90%	14.50%	0.896 (0.644 to 1.247)	0.513
Combination of rare haplotypes (frequency <5%)		9.90%	11.10%

CI, confidence interval; OR, odds ratio; SLE, systemic lupus erythematosis; SNP, single nucleotide polymorphism.

ISSN: 1478-6362