Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23Rwith juvenile psoriatic arthritis

Table 1 Association analysis of IL23R (rs11209026) and ERAP1 (rs30187) SNPs in all JIA and stratified by subtype

	IL23R (rs11209026)				ERAP1 (rs30187)
ILAR subtype	MAF Cases	MAF Controls	PTrend	OR 95% CI	MAF Cases	MAF Controls	PTrend	OR 95% CI
All JIA	0.06	0.07	0.46	0.93 (0.78 to 1.12	0.34	0.33	0.65	1.02 (0.92 to 1.13
Systemic	0.08	0.07	0.44	1.17 (0.78 to 1.76)	0.35	0.33	0.56	1.07 (0.85 to 1.36)
Persistent oligoarthritis	0.07	0.07	0.85	1.03 (0.77 to 1.39)	0.31	0.33	0.31	0.91 (0.76 to 1.09)
Extended oligoarthritis	0.07	0.07	0.65	1.11 (0.71 to 1.72)	0.34	0.33	0.84	1.03 (0.80 to 1.32)
RF negative polyarthritis	0.06	0.07	0.5	0.88 (0.6 to 1.29)	0.30	0.33	0.19	0.86 (0.70 to 1.07)
RF positive oligoarthritis	0.07	0.07	0.93	0.97 (0.49 to 1.91)	0.39	0.33	0.22	1.26 (0.87 to 1.82)
Enthesitis related arthritis	0.04	0.07	0.15	0.52 (0.21 to 1.28)	0.46	0.33	0.005	1.69 (1.178 to 2.44)
Psoriatic arthritis	0.03	0.07	0.04	0.4 (0.16 to 0.98)	0.38	0.33	0.21	1.24 (0.88 to 1.74)

CI, confidence interval; ERAP1, endoplasmic reticulum aminopeptidase 1; IL23R, interleukin 23 receptor; JIA, juvenile idiopathic arthritis; MAF, minor allele frequency; OR, odds ratio.

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