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Table 1 Characteristics of the pre-patients (individuals before the onset of any symptoms of joint disease) and matched controls

From: Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis

  Pre-patients Controls
Number (% female) 71 (80.3) 276 (80.1)
Age (range), years 48.6 (19.6 to 66.9) 50.0 (18.6 to 69.1)
Smoking ever, n (%) 49 (69.0)*** 122/271 (45.0)
HLA-SE alleles, n (%) 38/68 (55.9)** 39/116 (33.6)
PTPN22 1858T, n (%) 28 (39.4)** 47/210 (22.4)
Anti-CCP2 antibodiesE (%) 23 (32.4)*** 4 (1.5)
IgM RF, n (%) 17 (22.4)*** 14 (5.1)
IgA RF, n (%) 28 (36.8)*** 12 (4.3)
IgG RF, n (%) 15 (19.7)*** 14 (5.1)
  1. **P < 0.01, ***P < 0.001, E analysed with a kit from Euro-Diagnostica. HLA-SE, human-leukocyte antigen - shared epitope; PTPN22, protein tyrosine phosphatase non-receptor type 22; Anti-CCP, anti-cyclic citrullinated peptide; Ig, immunoglobulin; RF, rheumatoid factor.