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Table 1 Characteristics of the pre-patients (individuals before the onset of any symptoms of joint disease) and matched controls

From: Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis

 

Pre-patients

Controls

Number (% female)

71 (80.3)

276 (80.1)

Age (range), years

48.6 (19.6 to 66.9)

50.0 (18.6 to 69.1)

Smoking ever, n (%)

49 (69.0)***

122/271 (45.0)

HLA-SE alleles, n (%)

38/68 (55.9)**

39/116 (33.6)

PTPN22 1858T, n (%)

28 (39.4)**

47/210 (22.4)

Anti-CCP2 antibodiesE (%)

23 (32.4)***

4 (1.5)

IgM RF, n (%)

17 (22.4)***

14 (5.1)

IgA RF, n (%)

28 (36.8)***

12 (4.3)

IgG RF, n (%)

15 (19.7)***

14 (5.1)

  1. **P < 0.01, ***P < 0.001, E analysed with a kit from Euro-Diagnostica. HLA-SE, human-leukocyte antigen - shared epitope; PTPN22, protein tyrosine phosphatase non-receptor type 22; Anti-CCP, anti-cyclic citrullinated peptide; Ig, immunoglobulin; RF, rheumatoid factor.