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Table 3 Sensitivity and specificity for various anti-CCP2 antibody isotypes for 71 pre-patients, 274 matched controls and 60 patients

From: Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis

Anti-CCP antibody Sensitivity Sensitivity Specificity
  pre-patients patients  
IgGP 33.8*** 71.7*** 98.9
IgAP 23.9*** 43.3*** 97.1
IgMaP 11.8 32.8*** 93.9
IgGE 32.4*** 71.2*** 98.5
  1. The cut-off values for positivity for the antibodies were calculated using ROC curves
  2. aAnalysis of IgM in pre-patients; n = 68, in patients; n = 58, and controls; n = 263, E analysed with a kit from Euro-Diagnostica, P analysed with a kit from Phadia.***P < 0.001. Anti-CCP, anti-cyclic citrullinated peptide; ROC, receiver operating characteristic; Ig, immunoglobulin.