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Table 4 Simple conditional logistic regression analyses of the different isotypes of anti-CCP2 antibodies, RFs, HLA-SE, PTPN22 1858T and smoking in pre-patients and matched controls

From: Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis

Factors

OR (95%CI)

P-value

IgG-CCP2

94.11 (12.74 to 695.41)

<0.0001

IgA-CCP2

11.07 (4.36 to 28.09)

<0.0001

IgM-CCP2

2.49 (0.98 to 6.29)

0.054

IgG RF

7.01 (2.82 to 17.42)

<0.0001

IgA RF

15.87 (6.53 to 38.58)

<0.0001

IgM RF

6.56 (2.77 to 15.50)

<0.0001

HLA-SE

2.91 (1.47 to 5.76)

0.002

PTPN22 1858T

2.18 (1.15 to 4.12)

0.017

Smoking

3.12 (1.73 to 5.63)

<0.0001

  1. Only one sample from each individual has been included in the analyses.
  2. Anti-CCP, anti-cyclic citrullinated peptide; HLA-SE, human-leukocyte antigen - shared epitope; PTPN22, protein tyrosine phosphatase non-receptor type 22; Ig, immunoglobulin.