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Table 4 Simple conditional logistic regression analyses of the different isotypes of anti-CCP2 antibodies, RFs, HLA-SE, PTPN22 1858T and smoking in pre-patients and matched controls

From: Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis

Factors OR (95%CI) P-value
IgG-CCP2 94.11 (12.74 to 695.41) <0.0001
IgA-CCP2 11.07 (4.36 to 28.09) <0.0001
IgM-CCP2 2.49 (0.98 to 6.29) 0.054
IgG RF 7.01 (2.82 to 17.42) <0.0001
IgA RF 15.87 (6.53 to 38.58) <0.0001
IgM RF 6.56 (2.77 to 15.50) <0.0001
HLA-SE 2.91 (1.47 to 5.76) 0.002
PTPN22 1858T 2.18 (1.15 to 4.12) 0.017
Smoking 3.12 (1.73 to 5.63) <0.0001
  1. Only one sample from each individual has been included in the analyses.
  2. Anti-CCP, anti-cyclic citrullinated peptide; HLA-SE, human-leukocyte antigen - shared epitope; PTPN22, protein tyrosine phosphatase non-receptor type 22; Ig, immunoglobulin.