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Table 5 Concentrations of cytokines, cytokine related factors and chemokines (median, IQR, pg/mL) in pre-patients stratified for the presence or absence of IgA and IgG isotypes of anti-CCP2 antibodies

From: Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis

  IgA positive IgA negative P-value IgG positive IgG negative P-value
  (n= 14) (n= 38)   (n= 20) (n= 32)  
Cytokine/chemokine
General activation       
   IL-1β 7.2 (2.9 to 36.4) 3.4 (2.3 to 5.1) 0.025 5.9 (2.3 to 25.5) 3.3 (2.3 to 4.9) 0.071
   IL-1Ra 164.6 (128.7 to 454.9) 144.1 (96.5 to 195.5) 0.089 162.9 (109.7 to 408.6) 144.1 (99.8 to 186.5) 0.136
   IL-2Rα 66.9 (38.6 to 110.0) 33.4 (22.3 to 51.3) 0.008 60.9 (35.9 to 88.7) 32.2 (20.8 to 47.6) <0.001
   TNFα 108.1 (3.0 to 506.7) 49.1 (25.7 to 118.6) 0.556 85.4 (27.2 to 224.0) 45.0 (20.8 to 112.9) 0.234
   IL-6 19.8 (5.9 to 147.7) 4.3 (1.1 to 11.5) 0.009 16.2 (3.6 to 111.6) 4.8 (1.1 to 8.2) 0.019
   IL-2 74.7 (2.8 to 141.5) 3.8 (1.1 to 18.3) 0.020 49.1 (10.5 to 106.8) 1.4 (1.1 to 11.7) <0.001
   IL-15 2.4 (0.2 to 9.6) 0.5 (0.2 to 4.2) 0.355 4.2 (0.8 to 4.2) 0.5 (0.2 to 4.2) 0.010
Th1 related       
   IL-12 54.4 (21.0 to 135.2) 21.2 (13.7 to 32.3) 0.033 53.5 (21.4 to 161.3) 20.5 (13.5 to 29.3) 0.012
   IFN-γ 113.4 (84.5 to 1711.0) 92.9 (50.5 to 150.1) 0.083 152.2 (97.1 to 1167.6) 78.5 (50.4 to 130.8) 0.022
Th2 related       
   IL-4 4.4 (3.2 to 26.4) 3.0 (2.2 to 4.2) 0.044 4.4 (3.3 to 17.4) 2.9 (2.3 to 4.0) 0.019
   IL-5 5.6 (1.3 to 12.0) 5.8 (3.3 to 7.7) 0.675 5.8 (1.3 to 12.0) 5.8 (3.6 to 7.3) 0.441
   IL-9 128.3 (22.7 to 283.6) 19.6 (5.7 to 85.9) 0.022 121.1 (24.7 to 255.9) 17.6 (5.6 to 71.7) 0.012
   IL-13 5.1 (3.6 to 11.2) 4.4 (2.9 to 6.7) 0.329 5.3 (3.9 to 17.0) 4.0 (3.0 to 6.5) 0.089
   Eotaxin 80.7 (43.2 to 429.8) 42.0 (26.1 to 53.1) 0.008 80.7 (44.0 to 363.8) 36.7 (26.0 to 47.6) 0.004
Th17 related       
   IL-17 31.3 (17.7 to 46.5) 22.3 (9.9 to 38.1) 0.082 31.5 (20.3 to 42.0) 21.2 (9.6 to 36.9) 0.040
Treg cell-related       
   IL-10 6.5 (3.8 to 19.8) 5.5 (3.6 to 8.1) 0.279 6.2 (3.2 to 18.4) 5.3 (3.9 to 7.6) 0.541
Bone marrow derived       
   IL-7 23.8 (19.2 to 36.8) 27.2 (18.6 to 37.4) 0.807 24.8 (13.4 to 42.1) 26.2 (20.8 to 36.6) 0.620
   GM-CSF 23.0 (12.9 to 103.4) 5.0 (2.5 to 23.9) 0.008 20.2 (5.5 to 62.0) 4.6 (2.5 to 15.7) 0.054
   G-CSF 57.1 (39.0 to 80.1) 58.7 (42.3 to 74.5) 0.463 57.1 (38.8 to 83.1) 58.7 (43.6 to 72.7) 0.527
Stromal cells and angiogenic factors       
   bFGF 6.7 (2.2 to 14.1) 6.6 (2.2 to 6.8) 0.187 2.9 (1.6 to 11.2) 6.6 (3.5 to 6.8) 0.519
   PDGF-BB 1905.9 (705.9 to 2387.4) 1985.6 (997.6 to 3160.0) 0.911 1975.9 (1109.6 to 3437.3) 1695.3 (950.6 to 2370.9) 0.312
   VEGF 24.6 (10.0 to 63.7) 13.1 (5.7 to 23.9) 0.029 28.6 (12.0 to 53.1) 11.7 (4.9 to 15.0) 0.022
Chemokines       
   MIF 367.1 (90.8 to 538.2) 223.0 (142.1 to 461.5) 0.919 384.5 (163.2 to 599.4) 207.8 (123.7 to 366.5) 0.095
   MIG 488.5 (319.0 to 1167.5) 272.9 (190.4 to 371.2) 0.004 425.6 (279.1 to 741.3) 272.9 (201.6 to 364.0) 0.039
   IL-8 7.7 (3.6 to 11.4) 5.0 (0.5 to 10.2) 0.263 6.4 (0.5 to 12.1) 6.6 (1.7 to 9.4) 0.975
   IP-10 962.1 (696.2 to 2214.2) 634.3 8425.0 to 1062.0) 0.014 957.0 (644.2 to 1855.8) 624.4 (420.0 to 1071.5) 0.061
   MCP-1 23.0 (19.0 to 62.4) 18.5 (12.8 to 28.4) 0.028 25.8 (17.6 to 52.7) 17.3 (12.9 to 26.3) 0.085
   MIP-1α 7.2 (4.2 to 11.7) 6.9 (4.8 to 10.0) 0.746 7.4 (2.9 to 11.9) 6.9 (5.1 to 9.3) 0.994
   MIP-1β 44.2 (37.6 to 49.7) 35.7 (26.5 to 42.2) 0.030 42.9 (31.4 to 48.7) 36.5 (27.4 to 41.1) 0.200
  1. IQR, inter quartile range; Ig, immunoglobulin; anti-CCP, anti-cyclic citrullinated peptide; IL, interleukin; TNF, tumor necrosis factor; IFN; interferon, GM-CSF, granulocyte macrophage colony stimulating factor; G-CSF, granulocyte colony stimulating factor; bFGF, basic-fibroblast growth factor; PDGF, platelet derived growth factor; VEGF, vascular endothelial growth factor; MIF, macrophage-migration inhibitory factor; MIG, monokine induced by interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein.