Figure 3

Effect of interleukin (IL)-17 on pannus-like tissue growth in the presence of indomethacin. Synovial tissue (ST)-derived inflammatory cells (n = 7) were incubated with an incremental dose of IL-17 in the absence or presence of indomethacin (100 to 1000 nM). Morphologic changes were observed under an inverted phase contrast microscope twice weekly for 4 weeks and were scored semiquantitatively on a scale of 0 to 4 according to the degree of tissue development as described in Materials and methods. Box and whisker plots indicate 25th/75th percentile and minimum/maximum, respectively. Bar indicates the median value. *P < 0.05 (by Wilcoxon signed-rank test).