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Figure 3 | Arthritis Research & Therapy

Figure 3

From: A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis

Figure 3

Flow cytometric enumeration of Th17 cells following a 5-day culture of peripheral blood mononuclear cells (PBMCs). (A) Representative flow cytometry histograms showing control PBMCs stained for CD4 and interleukin (IL)-17A after stimulation with anti-CD3, anti-CD3 and Th17 stimulatory conditions and anti-CD3 and Th17 stimulatory conditions with IL4. Numbers in quadrants represent the percentage of total cells expressing IL-17A. (B) Th17 and Th17/Th1 cell numbers generated in RA patient and control cultures. The difference between each cell type was statistically significant, P < 0.05, comparing the patient and control groups. I, isoleucine; V, valine.

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