Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Summary of human linkage studies in systemic lupus erythematosus

From: Genetic epidemiology: Systemic lupus erythematosus

  Moser et al Gaffney et al Gaffney et al Shai et al Lindqvist et al
Study parameter (1998) [15] (1998) [16] (2000) [17] (1999) [18] (2000) [19]
Number of families 94 105 82 80 19
Type of study Extended Sib-pair Sib-pair Extended Extended
  pedigrees    pedigrees pedigrees
Number of affected individuals 220 220 179 188 44
Number of unaffected individuals 313 155 101 246 52
Number of ethnic groups 2 5 4 2 1
Ethnicity of families studied      
   White 0 84 64 37 19
   Mexican American 0 0 0 43 0
   African American 31 6 12 0 0
   Hispanic 0 8 5 0 0
   European American 55 0 0 0 0
   Asian 0 3 0 0 0
   Mixed heritage 0 4 1 0 0
Number of loci analysed 312 341 366 350 336
Basis of linkage LOD = 1.5 LOD = 1.0 LOD = 1.0 NPLZ >1.5 LOD = 1.0
Statistical methods Model-based, Nonparametric Nonparametric Nonparametric Model-based
  then nonparametric     
  1. Information taken from from references [15,16,17,18,19]. LOD = logarithm of the odds; NPLZ = nonparametric linkage Zall statistic.