Table 2 Summary of human linkage studies in systemic lupus erythematosus
Moser et al | Gaffney et al | Gaffney et al | Shai et al | Lindqvist et al | |
|---|---|---|---|---|---|
Study parameter | (1998) [15] | (1998) [16] | (2000) [17] | (1999) [18] | (2000) [19] |
Number of families | 94 | 105 | 82 | 80 | 19 |
Type of study | Extended | Sib-pair | Sib-pair | Extended | Extended |
pedigrees | pedigrees | pedigrees | |||
Number of affected individuals | 220 | 220 | 179 | 188 | 44 |
Number of unaffected individuals | 313 | 155 | 101 | 246 | 52 |
Number of ethnic groups | 2 | 5 | 4 | 2 | 1 |
Ethnicity of families studied | |||||
White | 0 | 84 | 64 | 37 | 19 |
Mexican American | 0 | 0 | 0 | 43 | 0 |
African American | 31 | 6 | 12 | 0 | 0 |
Hispanic | 0 | 8 | 5 | 0 | 0 |
European American | 55 | 0 | 0 | 0 | 0 |
Asian | 0 | 3 | 0 | 0 | 0 |
Mixed heritage | 0 | 4 | 1 | 0 | 0 |
Number of loci analysed | 312 | 341 | 366 | 350 | 336 |
Basis of linkage | LOD = 1.5 | LOD = 1.0 | LOD = 1.0 | NPLZ >1.5 | LOD = 1.0 |
Statistical methods | Model-based, | Nonparametric | Nonparametric | Nonparametric | Model-based |
then nonparametric |