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Table 1 Characteristics and serum FSTL1 levels of the subjects investigateda

From: Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis

Characteristics RA ReA PsA AS CD UC SLE pSS sSS SSc PM/DM HC
Total number of subjects 207 22 34 33 20 22 40 16 28 22 43 69
Ageb, years 54 23.5 46.5 44 33 35 37 50 53 53.5 41 38
25th percentile 43.5 13.8 33 29.5 25.5 29.3 31.3 48 39.3 43.5 26 27
75th percentile 63 33.5 54 51 43 45.8 52.3 63 63 58 58 41
Number of female/male subjects 159/48 8/14 15/19 9/24 6/14 9/13 34/6 14/2 24/4 17/5 31/12 37/32
Disease durationb, years 3 20 days 5 2 3 4 4 2 3 2 1 -
25th percentile 0.5 13 days 3 1 1 2 1 1 1 1 0.3 -
75th percentile 10 75 days 7 4 6 7 6 4 8 5 2 -
Serum FSTL1 levels, μg/l             
Geometric mean 74.28 3.74 7.57 6.19 6.39 13.61 14.60 29.94 73.88 16.48 13.79 6.49
Lower 95% CI 60.89 2.73 4.99 5.03 5.35 9.71 10.49 15.76 45.79 7.81 9.97 5.89
Upper 95% CI 90.60 5.12 11.48 7.62 7.63 19.06 20.30 56.88 119.20 34.76 19.06 7.15
RSD (%) 129.17 104.58 134.90 63.33 39.06 112.35 115.27 148.22 117.81 133.00 186.28 36.71
Median 71.27 3.71 4.52 5.21 6.05 10.78 12.92 34.81 82.48 25.01 10.74 6.60
25th percentile 25.51 2.49 3.47 3.67 4.92 7.48 6.84 10.51 23.48 3.38 6.76 5.28
75th percentile 236.70 5.46 29.59 9.37 8.55 28.24 34.12 47.37 169.70 62.68 29.60 8.19
Above normal, %c 87.43 9.09 26.47 18.18 5 36.36 52.5 68.75 96.43 54.55 48.84 4.3
P versus HC <0.001 <0.001 0.100 0.375 0.627 <0.001 <0.001 <0.001 <0.001 <0.001 0.018 -
P versus RA - <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 0.013 0.937 <0.001 <0.001 <0.001
  1. aFSTL1, follistatin-like protein 1; 95% CI, 95% confidence interval; -, not determined; RSD, relative standard deviation; HC, healthy individuals; RA, rheumatoid arthritis; ReA, reactive arthritis; PsA, psoriatic arthritis; AS, ankylosing spondylitis; CD, Crohn's disease; UC, ulcerative colitis; SLE, systemic lupus erythematosus; pSS, primary Sjögren's syndrome; sSS, secondary Sjögren's syndrome; SSc, systemic sclerosis; PM/DM, polymyositis/dermatomyositis; bmedian; cnormal range denoted as mean + 2 SD was 12 μg/l.