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Table 1 Test values of antiribosomal PNH, PR0, PR1 and PR2 antibodies calculated in receiver-operating characteristics analysisa

From: Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus

Statistics aRibP N H aRibP R 0 aRibP R 1 aRibP R 2 Anti-Sm Anti-dsDNA Farr assay Anti-dsDNA ELISA
Area under curve 0.7014 0.7368b 0.5811 0.6220 0.6791 0.8463 0.8621
95% CI 0.65 to 0.75 0.69 to 0.79 0.52 to 0.64 0.57 to 0.67 0.62 to 0.74 0.80 to 0.89 0.82 to 0.90
P value <0.0001 <0.0001 0.0021 <0.0001 <0.0001 <0.0001 <0.0001
Sensitivity at 95% specificity cutoff 24.4% (4.5) 29.2% (2.7)b 20.4% (6.6) 20.2% (10.5) 38.7% (2.0) 61.4% (5.4) 53.9% (73.9)
Sensitivity at 98% specificity cutoff 19.1% (6.7) 22.0% (3.7)b 16.1% (8.4) 17.9% (12.1) 33.7% (2.4) 56.4% (6.5) 42.9% (105.8)
Sensitivity at 99% specificity cutoff 14.3% (9.4) 22.0% (4.2)b 10.7% (13.0) 14.9% (13.9) 19.6% (4.8) 55.8% (6.8) 37.4% (151.0)
Sensitivity at 100% specificity cutoff 11.9 (11.5)b 11.3% (9.1) 8.9% (14.7) 11.3% (17.4) 12.3% (7.9) 49.1% (9.0) 31.3% (169.0)
Maximum sum of specificity and sensivity 133.2% 140.7%b 118.2% 117.9% 138.9% 161.8% 160.8%
  1. aaRibPNH, antibody against native ribosomal P heterocomplex; aRibPR0, antibody against recombinant ribosomal P0 protein; aRibPR1, antibody against recombinant ribosomal P1 protein; aRibPR2, antibody against recombinant ribosomal P2 protein; anti-Sm, anti-Smith antibody; anti-dsDNA, anti-double-stranded DNA antibody; ELISA, enzyme-linked immunosorbent assay; 95% CI, 95% confidence interval; bhighest values of sensitivity, area under the curve and lowest cutoff values (in parentheses) among autoantibodies against ribosomal P protein (aRibP).