Table 1 Test values of antiribosomal PNH, PR0, PR1 and PR2 antibodies calculated in receiver-operating characteristics analysisa
Statistics | aRibP N H | aRibP R 0 | aRibP R 1 | aRibP R 2 | Anti-Sm | Anti-dsDNA Farr assay | Anti-dsDNA ELISA |
|---|---|---|---|---|---|---|---|
Area under curve | 0.7014 | 0.7368b | 0.5811 | 0.6220 | 0.6791 | 0.8463 | 0.8621 |
95% CI | 0.65 to 0.75 | 0.69 to 0.79 | 0.52 to 0.64 | 0.57 to 0.67 | 0.62 to 0.74 | 0.80 to 0.89 | 0.82 to 0.90 |
P value | <0.0001 | <0.0001 | 0.0021 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
Sensitivity at 95% specificity cutoff | 24.4% (4.5) | 29.2% (2.7)b | 20.4% (6.6) | 20.2% (10.5) | 38.7% (2.0) | 61.4% (5.4) | 53.9% (73.9) |
Sensitivity at 98% specificity cutoff | 19.1% (6.7) | 22.0% (3.7)b | 16.1% (8.4) | 17.9% (12.1) | 33.7% (2.4) | 56.4% (6.5) | 42.9% (105.8) |
Sensitivity at 99% specificity cutoff | 14.3% (9.4) | 22.0% (4.2)b | 10.7% (13.0) | 14.9% (13.9) | 19.6% (4.8) | 55.8% (6.8) | 37.4% (151.0) |
Sensitivity at 100% specificity cutoff | 11.9 (11.5)b | 11.3% (9.1) | 8.9% (14.7) | 11.3% (17.4) | 12.3% (7.9) | 49.1% (9.0) | 31.3% (169.0) |
Maximum sum of specificity and sensivity | 133.2% | 140.7%b | 118.2% | 117.9% | 138.9% | 161.8% | 160.8% |