|
Statistics
|
aRibP
N
H
|
aRibP
R
0
|
aRibP
R
1
|
aRibP
R
2
|
Anti-Sm
|
Anti-dsDNA Farr assay
|
Anti-dsDNA ELISA
|
|---|
|
Area under curve
|
0.7014
|
0.7368b
|
0.5811
|
0.6220
|
0.6791
|
0.8463
|
0.8621
|
|
95% CI
|
0.65 to 0.75
|
0.69 to 0.79
|
0.52 to 0.64
|
0.57 to 0.67
|
0.62 to 0.74
|
0.80 to 0.89
|
0.82 to 0.90
|
|
P value
|
<0.0001
|
<0.0001
|
0.0021
|
<0.0001
|
<0.0001
|
<0.0001
|
<0.0001
|
|
Sensitivity at 95% specificity cutoff
|
24.4% (4.5)
|
29.2% (2.7)b
|
20.4% (6.6)
|
20.2% (10.5)
|
38.7% (2.0)
|
61.4% (5.4)
|
53.9% (73.9)
|
|
Sensitivity at 98% specificity cutoff
|
19.1% (6.7)
|
22.0% (3.7)b
|
16.1% (8.4)
|
17.9% (12.1)
|
33.7% (2.4)
|
56.4% (6.5)
|
42.9% (105.8)
|
|
Sensitivity at 99% specificity cutoff
|
14.3% (9.4)
|
22.0% (4.2)b
|
10.7% (13.0)
|
14.9% (13.9)
|
19.6% (4.8)
|
55.8% (6.8)
|
37.4% (151.0)
|
|
Sensitivity at 100% specificity cutoff
|
11.9 (11.5)b
|
11.3% (9.1)
|
8.9% (14.7)
|
11.3% (17.4)
|
12.3% (7.9)
|
49.1% (9.0)
|
31.3% (169.0)
|
|
Maximum sum of specificity and sensivity
|
133.2%
|
140.7%b
|
118.2%
|
117.9%
|
138.9%
|
161.8%
|
160.8%
|
- aaRibPNH, antibody against native ribosomal P heterocomplex; aRibPR0, antibody against recombinant ribosomal P0 protein; aRibPR1, antibody against recombinant ribosomal P1 protein; aRibPR2, antibody against recombinant ribosomal P2 protein; anti-Sm, anti-Smith antibody; anti-dsDNA, anti-double-stranded DNA antibody; ELISA, enzyme-linked immunosorbent assay; 95% CI, 95% confidence interval; bhighest values of sensitivity, area under the curve and lowest cutoff values (in parentheses) among autoantibodies against ribosomal P protein (aRibP).
