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Table 2 In vitro effects of methotrexate, etanercept, adalinumab, certolizumab, tocilizumab and hydroxychloroquine on K2P5.1 expression levels

From: Expression of K2P5.1 potassium channels on CD4+T lymphocytes correlates with disease activity in rheumatoid arthritis patients

Substance Concentration (μm) CD4 T cells, unstimulated CD4 T cells, stimulated
control -- 1.00 1.00
methotrexate 20 μM 1.08 ± 0.18 0.93 ± 0.08
etanercept 10 μg/ml 0.97 ± 0.07 1.01 ± 0.04
adalinumab 10 μg/ml 0.96 ± 0.14 1.12 ± 0.05
certolizumab 10 μg/ml 0.99 ± 0.09 1.14 ± 0.08
tocilizumab 10 μg/ml 1.12 ± 0.22 1.24 ± 0.15
hydroxychloroquine 2 μg/ml 0.82 ± 0.3 0.84 ± 0.35
  1. Normalized values of K2P5.1 expression are depicted as mean ± SE.