| |
Radiographic OA
|
Mean
|
SE
|
95% CI of the mean
|
P-value
|
95% CI for difference
|
|---|
| | | | |
Lower
|
Upper
| | |
|---|
|
sC2C
|
K/L1
|
5.56
|
0.04
|
5.49
|
5.64
|
0.06
|
-0.09 to 0.30
|
|
Ln (pmol/ml)
|
K/L2
|
5.42
|
0.07
|
5.29
|
5.55
| | |
|
sCPII
|
K/L1
|
7.53
|
0.06
|
7.38
|
7.64
|
<0.01*
|
0.26 to 0.78
|
|
Ln (ng/ml)
|
K/L2
|
6.99
|
0.11
|
6.77
|
7.21
| | |
|
uCTX-II/Cr
|
K/L1
|
5.25
|
0.13
|
4.99
|
5.52
|
0.15
|
-0.94 to 0.15
|
|
Ln (ng/μmol creatinine)
|
K/L2
|
5.65
|
0.23
|
5.19
|
6.11
| | |
|
sC2C/sCPII
|
K/L1
|
0.14
|
0.02
|
0.10
|
0.18
|
<0.01*
|
-0.21 to -0.04
|
| |
K/L2
|
0.26
|
0.04
|
0.19
|
0.34
| | |
|
uCTX-II/sCPII
|
K/L1
|
0.11
|
0.06
|
-0.01
|
0.22
|
<0.01*
|
-0.68 to -0.22
|
| |
K/L2
|
0.56
|
0.10
|
0.37
|
0.75
| | |
|
uNTx/Cr
|
K/L1
|
3.79
|
0.10
|
3.60
|
3.98
|
0.10
|
-1.47 to -0.59
|
|
Ln (ng/ml creatinine)
|
K/L2
|
3.46
|
0.16
|
3.13
|
3.79
| | |
|
sHA
|
K/L1
|
2.97
|
0.12
|
2.74
|
3.21
|
<0.01*
|
-1.21 to -0.27
|
|
Ln (pmol/ml)
|
K/L2
|
3.71
|
0.20
|
3.31
|
4.11
| | |
- All analyses were adjusted for age, gender, and body mass index. The urinary biomarkers were corrected for creatinine. The number of subjects with K/L grade 1 was 30, while that with K/L grade 2 was 16. *P-values less than or equal to 0.05 are statistically significant. 95% CI, 95% confidence interval; C2C, cartilage collagen type II cleavage; CPII, cartilage type II collagen carboxy propeptide; CTX-II, type II collagen C-telopeptide; HA, hyaluronic acid; K/L, Kellgren-Lawrence grade; Ln, natural log; NTx, N-terminal crosslinking telopeptide of type I collagen; SE, standard error of the mean; s, serum; u, urine.
