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Table 1 Proteoglycans (PGs) and proteins of the cartilage extracellular matrix

From: Articular cartilage and changes in Arthritis: Noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage

Proteoglycans

Proteins

Aggregating

Structural

   Aggrecan

   COMP (Thrombospondin-5)

   Versican

   Thrombospondin-1 and -3

   Link protein

   CMP (Matrilin-1)

Leucine-rich repeat

   Matrilin-3

   Biglycan (DS-PGI)

   CILP

   Decorin (DS-PGII)

   C-type lectin

   Epiphycan (DS-PGIII)

   Fibronectin

   Fibromodulin

   PRELP

   Lumican

   Chondroadherin

Other

   Tenascin-C

   Perlecan

   Fibrillin

   SZP/Lubricin

   Elastin

 

Regulatory

 

   gp-39/YKL-40

 

   Matrix gla protein/ MGP

 

   Pleiotrophin

 

   Chondromodulin-I/SCGP

 

   Chondromodulin-II

 

   CD-RAP

 

   Growth factors

 

Other

 

   Chondrocalcin

 

   PARP

 

   Lysozyme

 

   Phospholipase A2

 

   Proteinases and inhibitors

  1. CD-RAP = cartilage-derived retinoic acid responsive protein; CILP = cartilage intermediate layer protein; CMP = cartilage matrix protein; COMP = cartilage oligomeric matrix protein; DS-PG(I, II, III) = dermatan sulfate proteoglycan (I, II, III); gla = gamma-carboxyglutamic acid; gp = glycoprotein; PARP = proline- and arginine-rich protein; PRELP = proline- and arginine-rich end leucine-rich repeat protein; SZP = superficial zone protein.