Articular cartilage and changes in Arthritis: Noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage

Table 2 Genetic disorders and the mutant cartilage matrix proteoglycans and proteins with which they are associated

Mutant matrix molecule	Associated disorder¹
Aggrecan (impaired core	Cartilage matrix deficiency (in mice)
protein synthesis)	Nanomelia (in chickens)
	Brachymorphism (in mice)
Aggrecan (impaired	Diastrophic dysplasia
glycosaminoglycan sulfation)	Achondrogenesis 1B
	Atelosteogenesis type II
Perlecan	Chondrodystrophic myotonia
	Dyssegmental dysplasia
SZP	Camptodactyly-arthropathy-
	coxa vara-pericarditis syndrome
COMP	Pseudoachondroplasia
	Multiple epiphyseal dysplasia

¹Human disorder unless indicated otherwise. COMP = cartilage oligomeric protein; SZP = superficial zone protein.

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