Figure 3

OPN301 significantly inhibited cytokine production in SFMC compared to IgG isotype control. RA SFMCs (n = 6) were stimulated with Pam3CSK4 in the presence or absence of OPN301 (1 μg/ml) or matched IgG isotype control for six hours. Values are expressed as the mean ± SEM. * P < 0.05, significantly different from control as determined using Wilcoxon Signed Rank analysis.