Patient
|
Dose (mg)
|
Cmax (μg/mL)
|
Tmax (d)
|
AUC0-∞ (μgd/mL)
|
t1/2 (d)
|
CL/F(L/d)
|
Vz/F(L)
|
CL/F/wt(L/d)/kg
|
---|
1
|
34.8
|
NE
|
NE
|
NE
|
NE
|
NE
|
NE
|
NE
|
2
|
36.0
|
13.6
|
6.96
|
580
|
25.7
|
0.0621
|
2.3
|
0.0034
|
3
|
46.6
|
7.67
|
2
|
NE
|
NE
|
NE
|
NE
|
NE
|
4
|
48.0
|
NE
|
NE
|
NE
|
NE
|
NE
|
NE
|
NE
|
5
|
71.0
|
12.4
|
2
|
543
|
23.7
|
0.131
|
4.48
|
0.0037
|
6
|
150.0
|
16.3
|
7.05
|
647
|
22.9
|
0.232
|
7.67
|
0.0048
|
7
|
150.0
|
10.4
|
2.16
|
NE
|
NE
|
NE
|
NE
|
NE
|
- NE: : non-estimable
- Cmax, Maximum (peak) serum drug concentration after drug administration; Tmax, Time to reach peak or maximum concentration following drug administration; AUC0∞, Area under the concentration-time curve from time zero to infinity; t1/2, The elimination half-life associated with the terminal slope (λz) of a semi logarithmic concentration-time curve; CL/F, The apparent total clearance from serum; Vz/F, The apparent volume of distribution during terminal phase