Histopathological alterations in the skin of SSc patients. All photographs were taken at ×200 magnification. (A) Entrapment of an eccrine sweat gland. (B) Focal exocytosis (arrow). (C) Intima proliferation in a deep arteriole. (D) Parakeratosis (arrow). (E) Pigment incontinence (arrow). (F) Telangiectasia. (A and C-F) Haematoxylin and eosin staining. (B) Anti-CD3 staining.