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Table 1 Overview of the skin histology parameters and scoring systema

From: Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study

Method Parameter Scoring system
Histology (H&E) Epidermal pigmentation 10-cm VAS
Histology (MT) Hyalinised collagen 10-cm VAS [7]
IHC (α-SMA) Myofibroblasts 10-cm VAS [7]
Histology (H&E) Mean epidermal thickness Semiquantitative
Histology (H&E) Mononuclear cellular infiltration Semiquantitative [14]
Histology (CI) Mucin deposition in deep dermis Semiquantitative [16]
Histology (H&E) Calcification Present or absent
Histology (MT) Entrapment of an eccrine sweat gland Present or absent
Histology (H&E) Fibroplasia Present or absent
IHC (CD3) Focal exocytosis Present or absent
Histology (H&E) Loss of adnexae Present or absent
Histology (H&E) Loss of epidermal papillae Present or absent
Histology (H&E) Intima proliferation of deep arterioles Present or absent
Histology (H&E) Parakeratosis Present or absent
Histology (H&E) Pigment incontinence Present or absent
Histology (H&E) Telangiectasia in papillary dermis Present or absent
  1. aα-SMA, α-smooth muscle actin; CI, colloidal iron; H&E, haematoxylin and eosin; IHC, immunohistochemistry; MT, Masson trichrome; VAS, Visual Analogue Scale.