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Table 3 Independent effect of intron 2 SNPs in the carriers of the 3' UTR risk genotypesa

From: TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

Risk genotype Study group, n(%)    
rs3853839 rs179019 rs179010 SLE (N= 322) Controls (N= 243) P OR 95% CI
G/G or G/C A/A T/T 42 (13.0) 14 (5.8)    
+ + + 280 (87.0) 229 (94.2) 0.0043 2.45 1.31 to 4.60
+ Others     Reference  
  1. aSNP, single-nucleotide polymorphism; 3' UTR, 3' untranslated region; OR, odds ratio; 95% CI, 95% confidence interval. Genotype frequencies are shown in parentheses (%). P value was calculated using Fisher's exact test.