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Table 4 Estimated haplotype frequencies in SLE and controlsa

From: TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

Haplotype rs179019 rs179010 rs3853839 SLE Controls Permutation P value
1 C C G 40.6% 38.0% 0.94
2 C C C 18.2% 24.1% 0.068
3b A T G 26.1% 20.3% 0.081
4 C T G 8.5% 8.8% 1.0
5 A T C 5.2% 5.6% 1.0
  1. aSLE, systemic lupus erythematosus; P values were calculated by permutation test (100,000 permutations) using HaploView version 4.0 software; beach haplotype was also tested for association under the recessive model. Individuals homozygous at all three SNPs were considered homozygous for the haplotype. Only haplotype 3 was significantly associated with SLE under the recessive model (SLE, 31 (9.0%) of 344; control, 11 (4.0%) of 274; P = 0.016 by Fisher's exact test; odds ratio 2.37, 95% confidence interval 1.17 to 4.80).