Haplotype | rs179019 | rs179010 | rs3853839 | SLE | Controls | Permutation P value |
|---|
1 | C | C | G | 40.6% | 38.0% | 0.94 |
2 | C | C | C | 18.2% | 24.1% | 0.068 |
3b | A | T | G | 26.1% | 20.3% | 0.081 |
4 | C | T | G | 8.5% | 8.8% | 1.0 |
5 | A | T | C | 5.2% | 5.6% | 1.0 |
- aSLE, systemic lupus erythematosus; P values were calculated by permutation test (100,000 permutations) using HaploView version 4.0 software; beach haplotype was also tested for association under the recessive model. Individuals homozygous at all three SNPs were considered homozygous for the haplotype. Only haplotype 3 was significantly associated with SLE under the recessive model (SLE, 31 (9.0%) of 344; control, 11 (4.0%) of 274; P = 0.016 by Fisher's exact test; odds ratio 2.37, 95% confidence interval 1.17 to 4.80).
