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Table 5 Association study of TLR7 SNPs with clinical characteristics of SLEa

From: TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

  

SLE total

Anti-Sm antibodies

Anti-dsDNA antibodies

Renal disorder

SNP

Model

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

rs3853839

Allele

0.017

1.36 (1.06 to 1.75)

0.032

1.65 (1.04 to 2.62)

0.014

1.40 (1.07 to 1.84)

0.025

1.40 (1.04 to 1.89)

rs179019

Recessive

0.016b

2.02 (1.15 to 3.54)

1.0b

0.89 (0.29 to 2.73)

0.029b

1.93 (1.07 to 3.48)

0.011b

2.25 (1.21 to 4.18)

rs179010

Recessive

0.018

1.75 (1.10 to 2.80)

0.67b

1.16 (0.51 to 2.67)

0.030

1.72 (1.05 to 2.83)

0.042

1.73 (1.02 to 2.95)

  1. aTLR7, Toll-like receptor 7 gene; SNP, single-nucleotide polymorphism; SLE, systemic lupus erythematosus; anti-Sm, anti-Smith; dsDNA, double-stranded DNA; OR, odds ratio, 95% CI, confidence interval; bFisher's exact test was used. Association was tested by χ2 analysis or Fisher's exact test using 2 × 2 contingency tables under the indicated model for rs3853839G, rs179019A and rs179010 T allele. All SLE as well as each SLE subset were compared with healthy controls.