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Table 5 Association study of TLR7 SNPs with clinical characteristics of SLEa

From: TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

   SLE total Anti-Sm antibodies Anti-dsDNA antibodies Renal disorder
SNP Model P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI)
rs3853839 Allele 0.017 1.36 (1.06 to 1.75) 0.032 1.65 (1.04 to 2.62) 0.014 1.40 (1.07 to 1.84) 0.025 1.40 (1.04 to 1.89)
rs179019 Recessive 0.016b 2.02 (1.15 to 3.54) 1.0b 0.89 (0.29 to 2.73) 0.029b 1.93 (1.07 to 3.48) 0.011b 2.25 (1.21 to 4.18)
rs179010 Recessive 0.018 1.75 (1.10 to 2.80) 0.67b 1.16 (0.51 to 2.67) 0.030 1.72 (1.05 to 2.83) 0.042 1.73 (1.02 to 2.95)
  1. aTLR7, Toll-like receptor 7 gene; SNP, single-nucleotide polymorphism; SLE, systemic lupus erythematosus; anti-Sm, anti-Smith; dsDNA, double-stranded DNA; OR, odds ratio, 95% CI, confidence interval; bFisher's exact test was used. Association was tested by χ2 analysis or Fisher's exact test using 2 × 2 contingency tables under the indicated model for rs3853839G, rs179019A and rs179010 T allele. All SLE as well as each SLE subset were compared with healthy controls.