High frequency of association of rheumatic/autoimmune diseases and untreated male hypogonadism with severe testicular dysfunction

Supplementary Table 2 Comparison of rheumatic/autoimmune diseases (RAD) and B27 frequency in male patients with hypogonadism (MPHG) and in controls (general population in Mexico City)

Condition	RAD/HGMP	(%)	RAD/controls	(%)	OR	95% CI	P ^a
RAD/no RAD	8/5	(61)	368/43445^b	(0.83)	188.89	55.9–665.91	<0.001
Ankylosing spondylitis	4/9	(30.7)	5/43832^b	(0.01)	2697.4	531.6–13586.8	<0.001
Systemic lupus erythematosus	2/11	(15.3)	15/43822^b	(0.03)	449.5	0–2391.1	<0.001
Polymyositis/dermatomyositis	1/12	(7.6)	18/43837^b	(0.04)	187.2	-	0.006
Juvenile rheumatoid arthritis	1/12	(7.6)	14/43823^b	(0.03)	-	-	0.004
Rheumatoid arthritis	0/13	(0)	272/43565^b	(0.62)	0.0	0–63.7	0.9
Other RAD^*	0/13	(0)	44/43793^b	(0.1)	0.0	0–407.1	0.9
B27 (+)/(-)	4/9	(30.7)	27/638^c	(4)	7.27	1.86–26.2	0.005

B27 = histocompatibility antigen B27; CI = confidence interval; OR = odds ratio; - = not calculable. ^aFisher exact test. ^bReference [32]. ^cReference [33]. ^*Other RAD = Sjogren's syndrome, mix connective tissue disease, scleroderma, rheumatic fever, reactive arthritis etc.

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