| Â | Cytokines (pg/ml) |
|---|
Groups | MIP-1α | RANTES | sRANKL | TNF-α | IL-6 | IL-4 | IL-10 |
|---|
Healthy | 30 ± 10 | <16 | <62 | 32 ± 20 | <62 | <10 | 28 ± 12 |
CIOA | 720 ± 55*** | 320 ± 24*** | 300 ± 70*** | 760 ± 56*** | 540 ± 68*** | 28 ± 16 | 38 ± 10 |
- Mice (n = 15 in each group) were injected i.a. with 1 U/mouse of collagenase on Day 0 and Day 2. Synovial extract was collected separately from each animal at Day 7 of CIOA and the level of several mediators was determined by ELISA; Student's t-test; ***P < 0.001 vs healthy mice.
- CIOA, collagen-induced osteoarthritis; ELISA, enzyme linked immunosorbent assay; IL, interleukin; MIP-1α, macrophage inflammatory protein 1α; sRANKL, soluble receptor activator of nuclear factor kappa B ligand; RANTES, regulated upon activation, normal T-cell expressed, and secreted protein; TNF, tumor necrosis factor.
