Skip to main content

Advertisement

Table 1 Chemokine and cytokine levels in the joint extracts on Day 7 of CIOA

From: Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine

  Cytokines (pg/ml)
Groups MIP-1α RANTES sRANKL TNF-α IL-6 IL-4 IL-10
Healthy 30 ± 10 <16 <62 32 ± 20 <62 <10 28 ± 12
CIOA 720 ± 55*** 320 ± 24*** 300 ± 70*** 760 ± 56*** 540 ± 68*** 28 ± 16 38 ± 10
  1. Mice (n = 15 in each group) were injected i.a. with 1 U/mouse of collagenase on Day 0 and Day 2. Synovial extract was collected separately from each animal at Day 7 of CIOA and the level of several mediators was determined by ELISA; Student's t-test; ***P < 0.001 vs healthy mice.
  2. CIOA, collagen-induced osteoarthritis; ELISA, enzyme linked immunosorbent assay; IL, interleukin; MIP-1α, macrophage inflammatory protein 1α; sRANKL, soluble receptor activator of nuclear factor kappa B ligand; RANTES, regulated upon activation, normal T-cell expressed, and secreted protein; TNF, tumor necrosis factor.