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Table 1 Effect of hyaluronan injection on the mean normalized stance and propulsion times of affected limbs in murine osteoarthritis modela

From: Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis

  Day 5 Day 12 Day 19
Measurement Mean (±SD) b Student's t-test Wilcoxon Mean (±SD) b Student's t-test Wilcoxon Mean (±SD) b Student's t-test Wilcoxon
Stance          
   OA (n = 14) 1.18 (0.24) 0.009 0.014 1.40 (0.47) 0.004 0.0001 1.43 (0.40) 0.0004 0.012
   OA + HA (n = 14) 1.05 (0.19) 0.48 0.39 1.10 (0.21) 0.19 0.12 0.99 (0.17) 0.89 0.84
   OA + saline (n = 8) 1.29 (0.14)c 0.0001 N.S. 1.24 (0.26) 0.002 0.004 1.32 (0.30) 0.01 0.04
Propulsion          
   OA (n = 14) 1.46 (0.43) 0.0005 0.002 1.28 (0.43) 0.025 0.024 1.61 (0.56) 0.0005 0.042
   OA + HA (n = 14) 1.19 (0.31) 0.11 0.15 1.26 (0.36) 0.06 0.13 0.94 (0.36) 0.66 N.S.
   OA + saline (n = 8) 1.78 (0.14)c 0.0006 N.S. 1.16 (0.43) 0.11 0.15 1.55 (0.18) 0.0001 0.008
  1. aSD, standard deviation; OA, osteoarthritis; HA, hyaluronan; N.S., P value outside the range of Wilcoxon probability tables; bdata represent the means (±SD) (n values provided in left column) of the normalized stance and propulsion times for each experimental group on each day. The value for each gait parameter in each hindlimb of each mouse was normalized to the corresponding pretreatment value for that mouse; cn = 4 mice for this experimental group. Values under Student's t-test and Wilcoxon rank-sum test headings are P values for the statistical significance of the difference between the means and unity.