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Table 2 Effect of hyaluronan injection on the mean of normalized stance and propulsion times of contralateral limb in murine osteoarthritis model

From: Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis

 

Day 5

Day 12

Day 19

Measurement

Mean (±SD) b

Student's t-test

Wilcoxon

Mean (±SD) b

Student's t-test

Wilcoxon

Mean (±SD) b

Student's t-test

Wilcoxon

Stance

         

   OA (n = 14)

1.10 (0.34)

0.29

0.52

1.16 (0.29)

0.051

0.078

1.03 (0.13)

0.51

0.54

   OA + HA (n = 14)

0.95 (0.15)

0.34

N.S.

1.10 (0.20)

0.15

0.080

1.10 (0.20)

0.15

0.080

   OA + saline (n = 8)

0.97 (0.06)c

0.23

N.S.

1.23 (0.26)

0.026

0.046

1.21 (0.26)

0.04

0.12

Propulsion

         

   OA (n = 14)

0.92 (0.41)

0.48

N.S.

1.11 (0.42)

0.34

0.35

1.16 (0.46)

0.21

0.34

   OA + HA (n = 14)

0.80 (0.21)

0.016

0.018

1.01 (0.19)

0.87

0.80

0.97 (0.20)

0.68

N.S.

   OA + saline (n = 8)

0.78 (0.25)c

0.02

N.S.

1.05 (0.14)

0.30

0.50

1.17 (0.52)

0.36

0.69

  1. aSD, standard deviation; OA, osteoarthritis; HA, hyaluronan; N.S., P value outside the range of Wilcoxon's probability tables; bdata) represent the means (±SD) (n values provided in left column) of the normalized stance and propulsion times for each experimental group on each day. The value for each gait parameter in each hindlimb of each mouse was normalized to the corresponding pretreatment value for that mouse; cn = 4 mice for this experimental group. Values under Student's t-test and Wilcoxon rank-sum test headings are P values for the statistical significance of the difference between the means and unity.