
Day 5

Day 12

Day 19


Measurement

Mean (±SD)
^{b}

Student's ttest

Wilcoxon

Mean (±SD)
^{b}

Student's ttest

Wilcoxon

Mean (±SD)
^{b}

Student's ttest

Wilcoxon


Stance
         
OA (n = 14)

1.10 (0.34)

0.29

0.52

1.16 (0.29)

0.051

0.078

1.03 (0.13)

0.51

0.54

OA + HA (n = 14)

0.95 (0.15)

0.34

N.S.

1.10 (0.20)

0.15

0.080

1.10 (0.20)

0.15

0.080

OA + saline (n = 8)

0.97 (0.06)^{c}

0.23

N.S.

1.23 (0.26)

0.026

0.046

1.21 (0.26)

0.04

0.12

Propulsion
         
OA (n = 14)

0.92 (0.41)

0.48

N.S.

1.11 (0.42)

0.34

0.35

1.16 (0.46)

0.21

0.34

OA + HA (n = 14)

0.80 (0.21)

0.016

0.018

1.01 (0.19)

0.87

0.80

0.97 (0.20)

0.68

N.S.

OA + saline (n = 8)

0.78 (0.25)^{c}

0.02

N.S.

1.05 (0.14)

0.30

0.50

1.17 (0.52)

0.36

0.69

 ^{a}SD, standard deviation; OA, osteoarthritis; HA, hyaluronan; N.S., P value outside the range of Wilcoxon's probability tables; ^{b}data) represent the means (±SD) (n values provided in left column) of the normalized stance and propulsion times for each experimental group on each day. The value for each gait parameter in each hindlimb of each mouse was normalized to the corresponding pretreatment value for that mouse; ^{c}n = 4 mice for this experimental group. Values under Student's ttest and Wilcoxon ranksum test headings are P values for the statistical significance of the difference between the means and unity.