TY - JOUR AU - Kawamoto, Toshio AU - Abe, Yoshiyuki AU - Ito, Jun AU - Makino, Fumihiko AU - Kojima, Yuko AU - Usui, Yoshihiko AU - Ma, Juan AU - Morimoto, Shinji AU - Yagita, Hideo AU - Okumura, Ko AU - Takasaki, Yoshinari AU - Akiba, Hisaya PY - 2011 DA - 2011/03/22 TI - Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells JO - Arthritis Research & Therapy SP - R47 VL - 13 IS - 2 AB - T cell immunoglobulin and mucin domain-2 (TIM-2) has been shown to regulate CD4 T cell activation. However, the role of TIM-2 in the autoimmune disease models has not been clarified yet. In this study, we investigated the effects of anti-TIM-2 monoclonal antibodies (mAbs) in collagen-induced arthritis (CIA) to determine whether TIM-2 contributes to the development of T helper (Th) 1 or Th17 cells and joint inflammation. SN - 1478-6354 UR - https://doi.org/10.1186/ar3288 DO - 10.1186/ar3288 ID - Kawamoto2011 ER -