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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells

Figure 6

Effect of anti-TIM-2 mAb treatment on serum anti-CII IgG titers. (a) DBA/1 mice were immunized with type II collagen (CII)/complete Freund's adjuvant (CFA) on day 0 and treated with RMT2-14 or control IgG from day 0 to day 17. Serum levels of anti-CII IgG1, IgG2a, and IgG2b were measured by ELISA on day 16 and 24 after immunization. (b) DBA/1 mice were immunized with CII/CFA on day 0 and treated with RMT2-25, RMT2-26, or control IgG from day 0 to day 17. Serum levels of anti-CII IgG1, IgG2a, and IgG2b were measured by ELISA on day 32. Results are expressed as the mean ± standard error of the mean of 10 mice in each group. *, P < 0.05; **, P < 0.01 as compared with control IgG. TIM, T cell immunoglobulin and mucin domain.

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