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Table 3 Nature of base-pair substitutions

From: Perturbations in the impact of mutational activity on Vλ genes in systemic lupus erythematosus

   Substitution to
   Nonproductive Vλ rearrangements Productive Vλ rearrangements
Region of          
substitution Substitution from T C A G T C A G
CDR T - 2.9 1.0 0.5 - 1.9 1.4 1.1
  C 2.9 - 0.2 3.4 3.0 - 1.1 1.3
  A 5.8 2.4 - 4.1 7.0 3.1 - 6.7
  G 7.8 5.3 5.8b - 6.1 4.7 6.9b -
FR T - 2.6 1.7 3.1 - 2.9 1.7 2.0
  C 7.5 - 3.4 4.1 6.8 - 2.0 4.5
  A 4.2 2.7 - 3.9 5.0 2.6 - 6.3
  G 5.3 3.4 15.8b - 5.3 4.8 11.7b -
Total T - 5.5 2.7 3.6 - 4.8 3.1 3.1
  C 10.4 - 3.6 7.5 9.8 - 3.1 5.8
  A 10.0 5.1 - 8.0a 12.0 5.7 - 13.0a
  G 13.1 8.7 21.6 - 11.4 9.5 18.6 -
  1. aComparison of nonproductive and productive Vλ genes; P < 0.05 (Χ2 test). bComparison between mutations in the CDRs and FRs; P < 0.005 (Χ2 test). CDR = complementarity-determining region; FR = framework region.