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Table 3 Nature of base-pair substitutions

From: Perturbations in the impact of mutational activity on Vλ genes in systemic lupus erythematosus

  

Substitution to

  

Nonproductive Vλ rearrangements

Productive Vλ rearrangements

Region of

         

substitution

Substitution from

T

C

A

G

T

C

A

G

CDR

T

-

2.9

1.0

0.5

-

1.9

1.4

1.1

 

C

2.9

-

0.2

3.4

3.0

-

1.1

1.3

 

A

5.8

2.4

-

4.1

7.0

3.1

-

6.7

 

G

7.8

5.3

5.8b

-

6.1

4.7

6.9b

-

FR

T

-

2.6

1.7

3.1

-

2.9

1.7

2.0

 

C

7.5

-

3.4

4.1

6.8

-

2.0

4.5

 

A

4.2

2.7

-

3.9

5.0

2.6

-

6.3

 

G

5.3

3.4

15.8b

-

5.3

4.8

11.7b

-

Total

T

-

5.5

2.7

3.6

-

4.8

3.1

3.1

 

C

10.4

-

3.6

7.5

9.8

-

3.1

5.8

 

A

10.0

5.1

-

8.0a

12.0

5.7

-

13.0a

 

G

13.1

8.7

21.6

-

11.4

9.5

18.6

-

  1. aComparison of nonproductive and productive Vλ genes; P < 0.05 (Χ2 test). bComparison between mutations in the CDRs and FRs; P < 0.005 (Χ2 test). CDR = complementarity-determining region; FR = framework region.