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Table 2 Distribution of phenotypic frequencies of HLA- A alleles

From: Associations between the HLA-Apolymorphism and the clinical manifestations of Behcet's disease

 

All subjects

OR (95% CI)

P

(Pc)

HLA-B*51non-carriers

OR (95% CI)

P

(Pc)

HLA-B*51carriers

OR (95% CI)

P

(Pc)

 

BD

N= 223

Control

N= 1,398

  

BD

N= 142

Control

N= 1,116

  

BD

N= 81

Control

N= 282

  

A*01:01

2

(0.9)

45

(3.2)

0.27

(0.07 to 1.13)

 

2

(1.4)

38

(3.4)

0.41

(0.10 to 1.70)

 

0

(0.0)

7

(2.5)

NA

 

A*02:01

77

(34.5)

433

(31.0)

1.18

(0.87 to 1.58)

 

46

(32.4)

359

(32.2)

1.01

(0.70 to 1.47)

 

31

(38.3)

74

(26.2)

1.74

(1.04 to 2.93)

0.035

(> 1.0)

A*02:03

4

(1.8)

19

(1.4)

1.33

(0.45 to 3.93)

 

3

(2.1)

19

(1.7)

1.25

(0.36 to 4.26)

 

1

(1.2)

0

(0.0)

NA

 

A*02:05

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

0

(0.0)

NA

 

A*02:06

35

(15.7)

250

(17.9)

0.85

(0.58 to 1.26)

 

18

(12.7)

193

(17.3)

0.69

(0.41 to 1.17)

 

17

(21.0)

57

(20.2)

1.05

(0.57 to 1.93)

 

A*02:07

27

(12.1)

89

(6.4)

2.03

(1.28 to 3.20)

0.002

(0.06)

19

(13.4)

80

(7.2)

2.00

(1.17 to 3.41)

0.010

(> 1.0)

8

(9.9)

9

(3.2)

3.32

(1.24 to 8.92)

0.031

(> 1.0)

A*02:10

0

(0.0)

13

(0.9)

NA

 

0

(0.0)

12

(1.1)

NA

 

0

(0.0)

1

(0.4)

NA

 

A*03:01

3

(1.4)

35

(2.5)

0.53

(0.16 to 1.74)

 

3

(2.1)

28

(2.5)

0.84

(0.25 to 2.79)

 

0

(0.0)

7

(2.5)

NA

 

A*03:02

1

(0.5)

6

(0.4)

1.05

(0.13 to 8.72)

 

1

(0.7)

5

(0.5)

1.58

(0.18 to 13.59)

 

0

(0.0)

1

(0.4)

NA

 

A*11:01

39

(17.5)

242

(17.3)

1.01

(0.70 to 1.47)

 

25

(17.6)

188

(16.9)

1.05

(0.67 to 1.67)

 

14

(17.3)

54

(19.2)

0.88

(0.46 to 1.69)

 

A*11:02

2

(0.9)

2

(0.1)

6.32

(0.89 to 45.08)

 

1

(0.7)

1

(0.1)

7.91

(0.49 to 127 to 13)

 

1

(1.2)

1

(0.4)

3.5

(0.22 to 56.58)

 

A*24:02

95

(42.6)

578

(41.3)

1.05

(0.79 to 1.40)

 

54

(38.0)

442

(39.6)

0.94

(0.65 to 1.34)

 

41

(50.6)

136

(48.2)

1.10

(0.67 to 1.80)

 

A*24:03

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

0

(0.0)

NA

 

A*24:04

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

0

(0.0)

NA

 

A*24:08

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

0

(0.0)

NA

 

A*24:20

1

(0.5)

2

(0.1)

3.14

(0.28 to 34.82)

 

1

(0.7)

2

(0.2)

3.95

(0.36 to 43.84)

 

0

(0.0)

0

(0.0)

NA

 

A*26:01

26

(11.7)

93

(6.7)

1.85

(1.17 to 2.93)

0.008

(0.24)

19

(13.4)

74

(6.6)

2.18

(1.27 to 3.72)

0.004

(0.12)

7

(8.6)

19

(6.7)

1.31

(0.53 to 3.23)

 

A*26:02

11

(4.9)

58

(4.2)

1.20

(0.62 to 2.32)

 

7

(4.9)

46

(4.1)

1.21 (0.53 to 2.73)

 

4

(4.9)

12

(4.3)

1.17

(0.37 to 3.72)

 

A*26:03

7

(3.1)

17

(1.2)

2.63

(1.08 to 6.42)

0.037

(> 1.0)

5

(3.5)

14

(1.3)

2.87

(1.02 to 8.10)

0.053

2

(2.5)

3

(1.1)

2.35

(0.39 to 14.34)

 

A*26:05

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

0

(0.0)

NA

 

0

(0.0)

1

(0.4)

NA

 

A*26:18

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

0

(0.0)

NA

 

A*29:01

2

(0.9)

28

(2.0)

0.44

(0.10 to 1.87)

 

2

(1.4)

24

(2.2)

0.65

(0.15 to 2.78)

 

0

(0.0)

4

(1.4)

NA

 

A*29:02

1

(0.5)

0

(0.0)

NA

 

1

(0.7)

0

(0.0)

NA

 

0

(0.0)

0

(0.0)

NA

 

A*30:01

8

(3.6)

74

(5.3)

0.67

(0.32 to 1.40)

 

7

(4.9)

63

(5.7)

0.87

(0.39 to 1.93)

 

1

(1.2)

11

(3.9)

0.31

(0.04 to 2.42)

 

A*30:04

12

(5.4)

31

(2.2)

2.51

(1.27 to 4.96)

0.006

(0.18)

11

(7.8)

26

(2.3)

3.52

(1.70 to 7.29)

0.002

(0.06)

1

(1.2)

5

(1.8)

0.69

(0.08 to 6.01)

 

A*31:01

22

(9.9)

160

(11.4)

0.85

(0.53 to 1.35)

 

10

(7.0)

98

(8.8)

0.79

(0.40 to 1.55)

 

12

(14.8)

62

(22.0)

0.62

(0.31 to 1.21)

 

A*31:11

0

(0.0)

1

(0.1)

NA

 

0

(0.0)

0

(0.0)

NA

 

0

(0.0)

1

(0.4)

NA

 

A*32:01

0

(0.0)

26

(1.9)

NA

 

0

(0.0)

25

(2.2)

NA

 

0

(0.0)

1

(0.4)

NA

 

A*33:03

43

(19.3)

405

(29.0)

0.59

(0.41 to 0.83)

0.003

(0.09)

33

(23.2)†

345

(30.9)

0.68

(0.45 to 1.02)

 

10

(12.4)

60

(21.3)

0.52

(0.25 to 1.07)

 

A*68:01

1

(0.5)

3

(0.2)

2.09

(0.22 to 20.23)

 

1

(0.7)

2

(0.2)

3.95

(0.36 to 43.85)

 

0

(0.0)

1

(0.4)

NA

 
  1. Values are presented as N (%). P (Pc) values are presented for those alleles with estimable OR (95% CI) and P-values of < 0.05.
  2. †P = 0.047 (HLA-B*51 negative vs. positive patients). BD, Behcet's disease; CI, confidence intervals; NA, not applicable; OR, odds ratio; Pc, corrected P
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