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Table 4 Associations between HLA- A alleles and clinical manifestations of BD

From: Associations between the HLA-Apolymorphism and the clinical manifestations of Behcet's disease

HLA alleles Group Phenotypic frequency
n(%)
OR (95% CI) P Pc
All subjects  
A*02:07 Patients with skin lesions (n = 180) 25 (13.9)    
  vs. Patients without skin lesions (n = 43) 2 (4.7) 3.31 (0.75 to 14.54) 0.095  
  vs. Controls (n = 1,398) 89 (6.4) 2.37 (1.48 to 3.31) <0.0005 <0.012
  Patients with arthritis (n = 125) 17 (13.6)    
  vs. Patients without arthritis (n = 98) 10 (10.2) 1.39 (0.60 to 3.18) 0.438  
  vs. Controls (n = 1,398) 89 (6.4) 2.32 (1.33 to 4.03) 0.002 0.048
A*26:01 Patients with uveitis (n = 85) 15 (17.7)    
  vs. Patients without uveitis (n = 138) 11 (8.0) 2.47 (1.08 to 5.68) 0.029  
  vs. Controls (n = 1,398) 93 (6.7) 3.01 (1.66 to 5.46) <0.0005 <0.012
A*30:04 Patients with vascular lesions (n = 33) 6 (18.2)    
  vs. Patients without vascular lesions (n = 190) 6 (3.2) 6.81 (2.05 to 22.66) 0.003  
  vs. Controls (n = 1,398) 31 (2.2) 9.80 (3.78 to 25.43) <0.0005 <0.012
  Patients with genital ulcers (n = 159) 10 (6.3)    
  vs. Patients without genital ulcers (n = 64) 2 (3.1) 2.08 (0.44 to 9.77) 0.516  
  vs. Controls (n = 1,398) 31 (2.2) 3.00 (1.42 to 6.16) 0.006 0.14
  Patients with positive pathergy test (n = 94) 8 (8.5)    
  vs. Patients with negative pathergy test (n = 88) 3 (3.4) 2.19 (0.74 to 6.46) 0.147  
  vs. Controls (n = 1,398) 31 (2.2) 4.10 (1.83 to 9.20) 0.002 0.048
HLA-B*51 non-carriers  
A*02:07 Patients with skin lesions (n = 109) 17 (15.6)    
  vs. Patients without skin lesions (n = 33) 2 (6.1) 2.86 (0.63 to 13.10) 0.243  
  vs. Controls (n = 1,116) 80 (7.2) 2.39 (1.36 to 4.21) 0.002 0.048
  Patients with arthritis (n = 83) 14 (16.9)    
  vs. Patients without arthritis (n = 59) 5 (8.5) 2.19 (0.74 to 6.46) 0.147  
  vs. Controls (n = 1,116) 80 (7.2) 2.63 (1.42 to 4.87) 0.002 0.048
A*26:01 Patients with uveitis (n = 48) 11 (22.9)    
  vs. Patients without uveitis (n = 94) 8 (8.5) 3.20 (1.19 to 8.59) 0.017  
  vs. Controls (n = 1,116) 74 (6.6) 4.19 (2.05 to 8.54) <0.0005 <0.012
A*30:04 Patients with vascular lesions (n = 24) 6 (25.0)    
  vs. Patients without vascular lesions (n = 118) 5 (4.2) 7.53 (2.08 to 27.28) 0.003  
  vs. Controls (n = 1,116) 26 (2.3) 13.97 (5.13 to 38.08) <0.00005 <0.0012
  Patients with genital ulcers (n = 106) 9 (8.5)    
  vs. Patients without genital ulcers (n = 36) 2 (5.6) 1.58 (0.32 to 7.67) 0.730  
  vs. Controls (n = 1,116) 26 (2.3) 3.89 (1.77 to 8.54) 0.002 0.048
  Patients with positive pathergy test (n = 57) 7 (12.3)    
  vs. Patients with negative pathergy test (n = 58) 3 (5.2) 2.57 (0.63 to 10.47) 0.203  
  vs. Controls (n = 1,116) 26 (2.3) 5.87 (2.43 to 14.17) 0.001 0.024
  1. CI, confidence interval; OR, odds ratio; Pc, P-values corrected for multiple testing.